A series of labeled phospholipid ether analogs was designed and synthesized as potential metabolic probes and tumor-specific imaging agents. These agents were designed to further understand the nature of the tumor-specific ether lipids. A $\rm\sp{13}C$-label was incorporated into each isomer of 1-O-octadecyl-2-O-methyl-glycerophosphocholine (Et-18-$\rm OCH\sb3)$ through the use of commercially-available stereospecific starting materials. The desired enantiomers were produced in $>$98% enantiomeric excess. 1-$\rm \lbrack\sp{13}C\rbrack$-octadecyloxyprop-3-ylphosphocholine, an achiral phospholipid ether was also synthesized. Enrichment at the labeled carbon atom was estimated at $>$99% by NMR methods and mass spectral analysis. These agents w...
AbstractThe capacity of the antineoplastic ether lipid 1-O-octadecyl-2-O-methyl-glycero-3-phosphocho...
Various phosphatidylethanol (PEth) derivatives, the corresponding reversed positional isomers (RPI-P...
Includes bibliographical references (pages 58-61)The synthesis and characterization of two fluorogen...
Radioiodinated analogs of the naturally-occurring alkyl lysophospholipid (ALP) were designed and syn...
A range of ether lipids that show in vitro antineoplastic activity were synthesised. These compounds...
The overall goal of my research was to explore various strategies for improving the targeting of met...
We have designed and synthesized two radioiodinated analogs of hexadecylphosphocholine in order to e...
This is an assay designed to examine the radioactive phosphorous incorporation when the molecule is ...
Radioiodinated analogs of natural-occurring phospholipid ethers (PLE) have been evaluated as noninva...
We have previously described the remarkable capacity of radioiodinated alkyl phospholipids to be seq...
dissertationPLases (phospholipases) participate in a wide variety of cellular signals for healthy an...
With the aim of being able to detect disregulated choline lipid metabolism in cancer and elucidate t...
AbstractSpin-labeled analogs of phospholipids have been used widely to characterize the biophysical ...
Imaging approaches that track biological molecules within cells are essential tools in modern bioche...
Phospholipids are fatty compounds containing nitrogen and phosphorus. Three molecular types are usua...
AbstractThe capacity of the antineoplastic ether lipid 1-O-octadecyl-2-O-methyl-glycero-3-phosphocho...
Various phosphatidylethanol (PEth) derivatives, the corresponding reversed positional isomers (RPI-P...
Includes bibliographical references (pages 58-61)The synthesis and characterization of two fluorogen...
Radioiodinated analogs of the naturally-occurring alkyl lysophospholipid (ALP) were designed and syn...
A range of ether lipids that show in vitro antineoplastic activity were synthesised. These compounds...
The overall goal of my research was to explore various strategies for improving the targeting of met...
We have designed and synthesized two radioiodinated analogs of hexadecylphosphocholine in order to e...
This is an assay designed to examine the radioactive phosphorous incorporation when the molecule is ...
Radioiodinated analogs of natural-occurring phospholipid ethers (PLE) have been evaluated as noninva...
We have previously described the remarkable capacity of radioiodinated alkyl phospholipids to be seq...
dissertationPLases (phospholipases) participate in a wide variety of cellular signals for healthy an...
With the aim of being able to detect disregulated choline lipid metabolism in cancer and elucidate t...
AbstractSpin-labeled analogs of phospholipids have been used widely to characterize the biophysical ...
Imaging approaches that track biological molecules within cells are essential tools in modern bioche...
Phospholipids are fatty compounds containing nitrogen and phosphorus. Three molecular types are usua...
AbstractThe capacity of the antineoplastic ether lipid 1-O-octadecyl-2-O-methyl-glycero-3-phosphocho...
Various phosphatidylethanol (PEth) derivatives, the corresponding reversed positional isomers (RPI-P...
Includes bibliographical references (pages 58-61)The synthesis and characterization of two fluorogen...