Add to ORKGThis research aimed to repress target genes by modulating their expression through rewriting of aberrant epigenetic landscapes, including DNA methylation and histone post-translational modifications, utilizing epigenetic repressor domains. The epigenetic repressor domains included KRAB, DNMT3A, UHRF1 and CSD, which were delivered via the epigenetic editing tools ZFs, TALEs and the CRISPR/dCas9 system. Our findings suggest that a combination of multiple epigenetic repressor domains targeting epigenetic marks involved in epigenetic cross-talk significantly repressed target genes
Recent studies have shed light on the role of epigenetic marks in certain diseases like cancer, type...
Millions of chromatin marks have been profiled across the human genome in dif- ferent tissues and ce...
Abstract Epigenetic mechanisms are essential to establish and safeguard cellular identities in mamma...
The discovery of CRISPR (clustered regularly interspaced short palindromic repeats) gene editing tec...
Precision epigenome editing has gained significant attention as a method to modulate gene expression...
A general approach for heritably altering gene expression has the potential to enable many discovery...
Distinct epigenomic profiles of histone marks have been associated with gene expression, but questio...
Development of CRISPR-based epigenome editing tools is important for the study and engineering of bi...
Epigenetic editing is a promising approach to modulate the local chromatin environment of target gen...
Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local...
SummaryGene silencing is instrumental to interrogate gene function and holds promise for therapeutic...
Cell-type specific gene expression programs are tightly linked to epigenetic modifications on DNA an...
For my PhD research we made use of Epigenetic Editing, a technique in which enzymes, coupled to DNA-...
Tools for sequence-specific DNA binding have opened the door to new approaches in investigating fund...
Dissecting the complex network of epigenetic modifications requires tools that combine precise recog...
Recent studies have shed light on the role of epigenetic marks in certain diseases like cancer, type...
Millions of chromatin marks have been profiled across the human genome in dif- ferent tissues and ce...
Abstract Epigenetic mechanisms are essential to establish and safeguard cellular identities in mamma...
The discovery of CRISPR (clustered regularly interspaced short palindromic repeats) gene editing tec...
Precision epigenome editing has gained significant attention as a method to modulate gene expression...
A general approach for heritably altering gene expression has the potential to enable many discovery...
Distinct epigenomic profiles of histone marks have been associated with gene expression, but questio...
Development of CRISPR-based epigenome editing tools is important for the study and engineering of bi...
Epigenetic editing is a promising approach to modulate the local chromatin environment of target gen...
Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local...
SummaryGene silencing is instrumental to interrogate gene function and holds promise for therapeutic...
Cell-type specific gene expression programs are tightly linked to epigenetic modifications on DNA an...
For my PhD research we made use of Epigenetic Editing, a technique in which enzymes, coupled to DNA-...
Tools for sequence-specific DNA binding have opened the door to new approaches in investigating fund...
Dissecting the complex network of epigenetic modifications requires tools that combine precise recog...
Recent studies have shed light on the role of epigenetic marks in certain diseases like cancer, type...
Millions of chromatin marks have been profiled across the human genome in dif- ferent tissues and ce...
Abstract Epigenetic mechanisms are essential to establish and safeguard cellular identities in mamma...