Used against a variety of tumours, doxorubicin (DOX), causes multiple side-effects in patients, especially in high doses required to control tumour growth. A drug delivery system (DDS) was developed to deliver DOX. Through DOX encapsulation into chitosan DDS, novel DOX microparticles (DMPs) were formed. Multiple optimisation steps produced DMPs which caused tumour cell death. Treatment of mice bearing tumours with DMP decreased tumour growth and spread, with no visible side-effects. There are plans to evaluate this delivery vehicle more closely towards clinical development and testing
Targeted drug delivery system- Formulation and evaluation of chitosan nanospheres containing Doxorub...
Chitosan–heparin nanoparticles (CS-HP NPs) can be used as potential nano-based platforms for develop...
The study reports the initial biological evaluation of targeted polymeric glycol chitosan vesicles a...
Used against a variety of tumours, doxorubicin (DOX), causes multiple side-effects in patients, espe...
Osteosarcoma (OS) is the most common primary bone cancer affecting children and adolescents. It is p...
A chitosan molecule form self-assembled nanoparticles that can encapsulate a quantity of drugs and d...
Objectives: Chitosan is a green (natural, abundant, biodegradable, biocompatible) biopolymer that ca...
The increase of cancer incidence on the last decades and the non-existence of totally ef-ficient the...
The current management of primary osteosarcoma (OS) and its secondary metastasis is limited by the l...
Chitosan is a green (natural, abundant, biodegradable, biocompatible)\ud biopolymer that can be form...
Objective: Doxorubicin (Dox) is used clinically against various neoplasias, but suffers from serious...
Tumor reinitiating cancer stem-like cells are responsible for cancer recurrence associated with conv...
To overcome the P-glycoprotein (P-gp)-induced multidrug resistance (MDR) of cancer cells, a novel co...
Doxorubicin (DOX) is a potent cancer chemotherapeutic agent, but its clinical use is severely limite...
Abstract Green chemistry has been a growing multidisciplinary field in recent years showing great pr...
Targeted drug delivery system- Formulation and evaluation of chitosan nanospheres containing Doxorub...
Chitosan–heparin nanoparticles (CS-HP NPs) can be used as potential nano-based platforms for develop...
The study reports the initial biological evaluation of targeted polymeric glycol chitosan vesicles a...
Used against a variety of tumours, doxorubicin (DOX), causes multiple side-effects in patients, espe...
Osteosarcoma (OS) is the most common primary bone cancer affecting children and adolescents. It is p...
A chitosan molecule form self-assembled nanoparticles that can encapsulate a quantity of drugs and d...
Objectives: Chitosan is a green (natural, abundant, biodegradable, biocompatible) biopolymer that ca...
The increase of cancer incidence on the last decades and the non-existence of totally ef-ficient the...
The current management of primary osteosarcoma (OS) and its secondary metastasis is limited by the l...
Chitosan is a green (natural, abundant, biodegradable, biocompatible)\ud biopolymer that can be form...
Objective: Doxorubicin (Dox) is used clinically against various neoplasias, but suffers from serious...
Tumor reinitiating cancer stem-like cells are responsible for cancer recurrence associated with conv...
To overcome the P-glycoprotein (P-gp)-induced multidrug resistance (MDR) of cancer cells, a novel co...
Doxorubicin (DOX) is a potent cancer chemotherapeutic agent, but its clinical use is severely limite...
Abstract Green chemistry has been a growing multidisciplinary field in recent years showing great pr...
Targeted drug delivery system- Formulation and evaluation of chitosan nanospheres containing Doxorub...
Chitosan–heparin nanoparticles (CS-HP NPs) can be used as potential nano-based platforms for develop...
The study reports the initial biological evaluation of targeted polymeric glycol chitosan vesicles a...