1 – DNA methylation quantification analysis in different human soft tussues for forensic purposes 2 – Whole exome sequencing data analysis for geneic alteration in heart malfunctioning

REPORT 1. DNA methylation plays quite an important role in the mammalian genomes absolute functions. With the advancement in the epigenetics, it has been shown that the DNA methylation is a variable factor with respect to the age, differentially present in different human tissue types and may also be influenced by different life styles. We designed a project of forensic genetics, to identify the human soft tissues, based on the quantification of DNA methylation at specific genomic regions of different human tissues. We used bisulphite (pyro) sequencing to quantify the DNA methylation and confirmed that the regions are different with respect to their DNA methylation content. This approach may serve in the future, as a powerful forensic platform not only as an identification tool for tissues of unknown nature but also to predict age, gender of the donor and time of the crime scene. REPORT 2. Sudden cardiac death (SCD) is an unexpected causality resulted by cardiac malfunctioning over a short stretch of time (