Functional brain alterations in acute sleep deprivation: An activation likelihoodestimation meta-analysis

Sleep deprivation (SD) is a common problem in modern societies, which leads to cognitive dysfunctions includingattention lapses, impaired working memory, hindering decision making, impaired emotional processing, and motorvehicle accidents. Numerous neuroimaging studies have investigated the neural correlates of SD, but these studieshave reported inconsistent results. Thus, we aimed to identify convergent patterns of abnormal brain functions due toacute SD. Based on the preferred reporting for systematic reviews and meta-analyses statement, we searched thePubMed database and performed reference tracking and finally retrieved 31 eligible functional neuroimaging studies.Then, we applied activation estimation likelihood meta-analysis and found reduced activity mainly in the rightintraparietal sulcus and superior parietal lobule. The functional decoding analysis using the BrainMap databaseindicated that this region is mostly related to visuospatial perception, memory and reasoning. The significant coactivationof this region using the BrainMap database were found in the left superior parietal lobule, intraparietalsulcus, bilateral occipital cortex, left fusiform gyrus and thalamus. This region also connected with the superior parietallobule, intraparietal sulcus, insula, inferior frontal gyrus, precentral, occipital and cerebellum through resting-statefunctional connectivity in healthy subjects. Taken together, our findings highlight the role of superior parietal cortex inSD