Computational modeling of protein interactions for biomedical applications

Trabajo presentado en el Programa de Seminarios del Centro de Investigación del Cáncer, celebrado en Salamanca, el 23 de marzo de 2018The most recent advances in genome sequencing technologies are beginning to make feasible the long-sought goal of personalized medicine and the precision diagnosis and treatment of many diseases. The next critical step will be the interpretation of genetic variants at the molecular level, based on the structural, functional and energetic description of the relevant biomolecules and their interactions. However, structural data is only available for a tiny fraction of all possible biomolecular interactions that exist in the cell. In this context, ab initio docking can help to provide atomic details on the existing interaction network maps. Our group works on the development of computational methodologies for the structural characterization and modeling of protein interactions, with applications to systems of biomedical interest. The ultimate goal of our computational models is to improve the interpretation of genomic variants, and the identification of new potential drugs targeting protein-protein interactions of therapeutic interest.N