Structural/functional matches and divergences of phytoprostanes and phytofurans with bioactive human oxylipins

Structure-activity relationship (SAR) constitutes a crucial topic to discover new bioactive molecules. This approach initiates with the comparison of a target candidate with a molecule or a collection of molecules and their attributed biological functions to shed some light in the details of one or more SARs and subsequently using that information to outline valuable application of the newly identified compounds. Thus, while the empiric knowledge of medicinal chemistry is critical to these tasks, the results retrieved upon dedicated experimental demonstration retrieved resorting to modern high throughput analytical approaches and techniques allow to overwhelm the constraints adduced so far to the successful accomplishment of such tasks. Therefore, the present work reviews critically the evidences reported to date on the occurrence of phytoprostanes and phytofurans in plant foods, and the information available on their bioavailability and biological activity, shedding some light on the expectation waken up due to their structural similarities with prostanoids and isoprostanes.This work was partially funded by the ‘Fundación Séneca de la Región de Murcia’ Grupo de Excelencia 19900/GERM/15 and the Spanish project AGL2017-83386-R fron the Spanish Ministry of Science, Innovation and Universities. This work is included in the framework of the collaboration between the Spanish Research Council (CEBAS-CSIC) and CNRS-University of Montpellier by ‘Projets Internationaux de Cooperation Scientifique’ (PICS-2015-261141). RDP and SM were supported by a Postdoctoral Contract Juan de la Cierva de Incorporación (ICJI-2015-25373) from the Ministry of Economy, Industry and Competitiveness of Spain and a PostDoctoral fellowship (ARDITI-CQM/2017/008-PDG) granted by ARDITI- CQM+ project M1420-01-0145-FEDER-000005, respectively.Peer reviewe