RNA polymerase I activation and hibernation: unique mechanisms for unique genes

7 p.-2 fig.In yeast, transcription of ribosomal DNA (rDNA) by RNA polymerase I (Pol I) is regulated by unique mechanisms acting at the level of the enzyme. Under stress situations such as starvation, Pol I hibernates through dimerization. When growth conditions are restored, dimer disassembly and Rrn3 binding drive enzyme activation and subsequent recruitment to rDNA.This work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) under Grant BFU2013-48374-P and by the Ramón Areces Foundation.Peer reviewe