Implementing a physiologically based toxicokinetic (PBTK) model describing the bioaccumulation of three perfluorinated substances in rainbow trout (Onchorynchus mykiss)

Polyfluoroalkyl and perfluoroalkyl substances (PFASs) are ubiquitous in the environment, in particular in aquatic systems. Their unique physicochemical properties, leading to their stability, give them a complex hazard profile. PFASs behave differently compared to “classical” organic compounds and the mechanisms of absorption, distribution and elimination (ADE) remain incompletely understood, especially in aquatic vertebrates in which some of them are bioaccumulated. The aim of the present study is to describe the fundamental processes involved in ADE mechanisms in rainbow trout (Oncorhynchus mykiss) exposed to three model PFASs (perfluorooctane sulfonic acid - PFOS, perfluorohexane sulfonic acid – PFHxS, and perfluorononanoic acid - PFNA) through their diet, using a physiologically based toxicokinetic (PBTK) model. Also, this model will take into account the growth of individuals during their exposure. To develop our PBTK model, bioaccumulation and tissue distribution data are collected by feeding rainbow trout with contaminated pellets for 28 days, followed by a depuration period. Since temperature influences several physiological processes, the experiments will be carried out at three different temperatures (8°C, 12°C and 18°C). This poster will show the first results of this project obtained until now and will illustrate the progression of the present PBTK model