Effect-based tools (EBT) based on estrogen receptor (ER) activation are widely used to monitor xeno-estrogens in environmental samples. We previously reported that established human (MELN cells, expressing hERα) and zebrafish (ZELHα cells expressing zfERα, ZELHβ2 cells expressing zfERβ2) reporter cell lines are robust, reliable and sensitive to detect well-known ER ligands. However, they can respond to surface water and effluents samples differently, with samples being selectively active either on human or zebrafish cells. Different responses may be due to non-identified active substances and/or interactions with other chemicals, as ER activation depends on the intrinsic potency of the chemical and on the cell context (e.g. metabolism). The...
The number of environmental chemical contaminants suspected to act as endocrine disruptor compounds ...
International audience: Zebrafish, Danio rerio, is increasingly used as an animal model to study the...
Benzophenone derivatives (BPs) are used as UV filters in many different products. These lipophilic c...
Effect-based tools (EBT) based on estrogen receptor (ER) activation are widely used to monitor xeno-...
Aquatic endocrine disrupting chemicals (EDCs) encompass a great diversity of chemicals that affect e...
Estrogens are present in all vertebrates, from telesots to mammals, which can bind to and activate e...
International audienceThe number of environmental chemical contaminants suspected to act as endocrin...
Most in vitro reporter gene assays used to assess estrogenic contamination are based on human estrog...
Over the last decade, assessment of exposure of fish to aquatic endocrine disrupting chemicals (EDCs...
Endocrine disrupting chemicals (EDCs) act on the endocrine system through multiple mechanisms of act...
In vitro cellular assays based on the stable expression of a reporter gene driven by estrogen recept...
Assessing the risk posed by complex environmental samples is a challenging task that requires reliab...
Monitoring of environmental estrogens has become a major concern to assess the quality of water bodi...
International audienceZebrafish is increasingly used as an animal model to study the effects of envi...
The number of environmental chemical contaminants suspected to act as endocrine disruptor compounds ...
International audience: Zebrafish, Danio rerio, is increasingly used as an animal model to study the...
Benzophenone derivatives (BPs) are used as UV filters in many different products. These lipophilic c...
Effect-based tools (EBT) based on estrogen receptor (ER) activation are widely used to monitor xeno-...
Aquatic endocrine disrupting chemicals (EDCs) encompass a great diversity of chemicals that affect e...
Estrogens are present in all vertebrates, from telesots to mammals, which can bind to and activate e...
International audienceThe number of environmental chemical contaminants suspected to act as endocrin...
Most in vitro reporter gene assays used to assess estrogenic contamination are based on human estrog...
Over the last decade, assessment of exposure of fish to aquatic endocrine disrupting chemicals (EDCs...
Endocrine disrupting chemicals (EDCs) act on the endocrine system through multiple mechanisms of act...
In vitro cellular assays based on the stable expression of a reporter gene driven by estrogen recept...
Assessing the risk posed by complex environmental samples is a challenging task that requires reliab...
Monitoring of environmental estrogens has become a major concern to assess the quality of water bodi...
International audienceZebrafish is increasingly used as an animal model to study the effects of envi...
The number of environmental chemical contaminants suspected to act as endocrine disruptor compounds ...
International audience: Zebrafish, Danio rerio, is increasingly used as an animal model to study the...
Benzophenone derivatives (BPs) are used as UV filters in many different products. These lipophilic c...