International audienceThe human HepaRG cell line has been established from a hepatocholangiocarcinoma and first described in 2002; it possesses bipotent properties allowing commitment into two cell lineages hepatocytes expressing various functions of mature hepatocytes and primitive biliary cells. HepaRG cells can retrodifferentiate and transdifferentiate. Mature HepaRG hepatocytes express most phase 1 (including the major cytochromes P450 3A4, 2B6, and 1A2) and phase 2 enzymes, as well as the main transporters involved in drug and bile acid metabolism and excretion, and exhibit appropriate responsiveness to prototypical inducers and inhibitors. They can remain functionally stable in a nonproliferative state for several weeks; meanwhile, th...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
International audienceThe human HepaRG cell line has been established from a hepatocholangiocarcinom...
International audienceThe HepaRG cell line is the first human cell line able to differentiate in vit...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
A major roadblock to the application of bioartificial livers is the need for a human liver cell line...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
ABSTRACT: HepaRG cells, a newly developed human hepatoma cell line, differentiate into hepatocyte-li...
A major roadblock to the application of bioartificial livers is the need for a human liver cell line...
A major roadblock to the application of bioartificial livers is the need for a human liver cell line...
A major roadblock to the application of bioartificial livers is the need for a human liver cell line...
A major roadblock to the application of bioartificial livers is the need for a human liver cell line...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
A major roadblock to the application of bioartificial livers is the need for a human liver cell line...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
International audienceThe human HepaRG cell line has been established from a hepatocholangiocarcinom...
International audienceThe HepaRG cell line is the first human cell line able to differentiate in vit...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
A major roadblock to the application of bioartificial livers is the need for a human liver cell line...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
ABSTRACT: HepaRG cells, a newly developed human hepatoma cell line, differentiate into hepatocyte-li...
A major roadblock to the application of bioartificial livers is the need for a human liver cell line...
A major roadblock to the application of bioartificial livers is the need for a human liver cell line...
A major roadblock to the application of bioartificial livers is the need for a human liver cell line...
A major roadblock to the application of bioartificial livers is the need for a human liver cell line...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
A major roadblock to the application of bioartificial livers is the need for a human liver cell line...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...
International audienceOf the hepatic cell lines developed for in vitro studies of hepatic functions ...