International audienceProinflammatory cytokines exert cytotoxic effects on β-cells, and are involved in the pathogenesis of type I and type II diabetes and in the drastic loss of β-cells following islet transplantation. Cytokines induce apoptosis and alter the function of differentiated β-cells. Although the MAP3 kinase tumor progression locus 2 (Tpl2) is known to integrate signals from inflammatory stimuli in macrophages, fibroblasts and adipocytes, its role in β-cells is unknown. We demonstrate that Tpl2 is expressed in INS-1E β-cells, mouse and human islets, is activated and upregulated by cytokines and mediates ERK1/2, JNK and p38 activation. Tpl2 inhibition protects β-cells, mouse and human islets from cytokine-induced apoptosis and pr...
Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 in...
Glucagon-like peptide-1 (GLP-1) has been shown to protect pancreatic β-cells against cytokine-induce...
Objective: Hyperglycemia and systemic inflammation, hallmarks of Type 2 Diabetes (T2D), can induce t...
A small-molecule inhibitor of the MAP3 Kinase TPL2 improves nutrient-induced bêta-cell dysfunction a...
OBJECTIVE—Activation of extracellular signal–regulated ki-nase-(ERK)-1/2 by cytokines in adipocytes ...
AIMS/HYPOTHESIS: The pro-inflammatory cytokines IL-1 and IFNgamma are critical molecules in immune-m...
Glucagon-like peptide-1 and its analogs may preserve pancreatic beta-cell mass by promoting resistan...
Glucagon-like peptide-1 and its analogs may preserve pancreatic beta-cell mass by promoting resistan...
Copyright © 2014 Hélène Ezanno et al.This is an open access article distributed under the Creative...
OBJECTIVE—Apoptotic destruction of insulin-producing pancreatic β-cells is involved in the etiology ...
The p38 mitogen-activated protein kinase (MAPK) pathway is involved in endoplasmic reticulum stress ...
OBJECTIVE: The pro-inflammatory cytokine interleukin-1 beta (IL-1 beta) generates pancreatic beta-ce...
AIMS/HYPOTHESIS: Proinflammatory cytokines contribute to beta cell destruction in type 1 diabetes, b...
Aims/hypothesis: Proinflammatory cytokines contribute to beta cell destruction in type 1 diabetes, b...
To characterize the differentiation events that selectively target insulin-producing cells to interl...
Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 in...
Glucagon-like peptide-1 (GLP-1) has been shown to protect pancreatic β-cells against cytokine-induce...
Objective: Hyperglycemia and systemic inflammation, hallmarks of Type 2 Diabetes (T2D), can induce t...
A small-molecule inhibitor of the MAP3 Kinase TPL2 improves nutrient-induced bêta-cell dysfunction a...
OBJECTIVE—Activation of extracellular signal–regulated ki-nase-(ERK)-1/2 by cytokines in adipocytes ...
AIMS/HYPOTHESIS: The pro-inflammatory cytokines IL-1 and IFNgamma are critical molecules in immune-m...
Glucagon-like peptide-1 and its analogs may preserve pancreatic beta-cell mass by promoting resistan...
Glucagon-like peptide-1 and its analogs may preserve pancreatic beta-cell mass by promoting resistan...
Copyright © 2014 Hélène Ezanno et al.This is an open access article distributed under the Creative...
OBJECTIVE—Apoptotic destruction of insulin-producing pancreatic β-cells is involved in the etiology ...
The p38 mitogen-activated protein kinase (MAPK) pathway is involved in endoplasmic reticulum stress ...
OBJECTIVE: The pro-inflammatory cytokine interleukin-1 beta (IL-1 beta) generates pancreatic beta-ce...
AIMS/HYPOTHESIS: Proinflammatory cytokines contribute to beta cell destruction in type 1 diabetes, b...
Aims/hypothesis: Proinflammatory cytokines contribute to beta cell destruction in type 1 diabetes, b...
To characterize the differentiation events that selectively target insulin-producing cells to interl...
Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 in...
Glucagon-like peptide-1 (GLP-1) has been shown to protect pancreatic β-cells against cytokine-induce...
Objective: Hyperglycemia and systemic inflammation, hallmarks of Type 2 Diabetes (T2D), can induce t...