BACKGROUND: High-grade soft tissue sarcomas are a heterogeneous, complex group of aggressive malignant tumors showing mesenchymal differentiation. Recently, soft tissue sarcomas have increasingly been classified on the basis of underlying genetic alterations; however, the role of aberrant DNA methylation in these tumors is not well understood and, consequently, the usefulness of methylation-based classification is unclear. RESULTS: We used the Infinium HumanMethylation27 platform to profile DNA methylation in 80 primary, untreated high-grade soft tissue sarcomas, representing eight relevant subtypes, two non-neoplastic fat samples and 14 representative sarcoma cell lines. The primary samples were partitioned into seven stable clusters. A cl...
Using a candidate gene approach we recently identified frequent methylation of the RASSF2 gene assoc...
Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed...
Approximately one-third of the patients with well-differentiated liposarcoma (WDLPS) will develop a ...
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They...
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. ...
Primary malignant bone tumours are rare cancers that are characterised by different genetic and epig...
Soft tissue sarcomas (STSs) are a rare and fascinating group of diseases that can be subdivided into...
Diagnosing bone and soft tissue neoplasms remains challenging because of the large number of subtype...
[Purpose] Recent studies revealed divergent gene expression patterns in Ewing sarcoma (EwS) with can...
Background: Atypical fibroxanthomas (AFX) and pleomorphic dermal sarcomas (PDS) are lesions of the s...
Background: Sarcomas are a heterogeneous group of rare malignant tumors with more than 100 subtypes....
The role of aberrant DNA methylation in Ewing sarcoma is not completely understood. The methylation ...
Soft tissue sarcomas (STS) are a highly aggressive and heterogeneous group of malignant mesenchymal ...
Silencing of genes by DNA methylation is a common phenomenon in many types of cancer. However, the g...
Oesophageal adenocarcinoma (OAC) is increasing in incidence and has a poor prognosis. Tumour derived...
Using a candidate gene approach we recently identified frequent methylation of the RASSF2 gene assoc...
Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed...
Approximately one-third of the patients with well-differentiated liposarcoma (WDLPS) will develop a ...
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They...
Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. ...
Primary malignant bone tumours are rare cancers that are characterised by different genetic and epig...
Soft tissue sarcomas (STSs) are a rare and fascinating group of diseases that can be subdivided into...
Diagnosing bone and soft tissue neoplasms remains challenging because of the large number of subtype...
[Purpose] Recent studies revealed divergent gene expression patterns in Ewing sarcoma (EwS) with can...
Background: Atypical fibroxanthomas (AFX) and pleomorphic dermal sarcomas (PDS) are lesions of the s...
Background: Sarcomas are a heterogeneous group of rare malignant tumors with more than 100 subtypes....
The role of aberrant DNA methylation in Ewing sarcoma is not completely understood. The methylation ...
Soft tissue sarcomas (STS) are a highly aggressive and heterogeneous group of malignant mesenchymal ...
Silencing of genes by DNA methylation is a common phenomenon in many types of cancer. However, the g...
Oesophageal adenocarcinoma (OAC) is increasing in incidence and has a poor prognosis. Tumour derived...
Using a candidate gene approach we recently identified frequent methylation of the RASSF2 gene assoc...
Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed...
Approximately one-third of the patients with well-differentiated liposarcoma (WDLPS) will develop a ...