Visible-light-induced Trifluoromethylation of highly functionalized arenes and heteroarenes in continuous flow

\u3cp\u3eWe report a continuous-flow protocol for the trifluoromethylation of arenes, heteroarenes, and benzofused heterocycles. This photoredox methodology relies on the use of solid sodium trifluoromethanesulfinate (CF \u3csub\u3e3\u3c/sub\u3e SO \u3csub\u3e2\u3c/sub\u3e Na) as the trifluoromethylating agent and the iridium complex [Ir{dF(CF \u3csub\u3e3\u3c/sub\u3e)ppy} \u3csub\u3e2\u3c/sub\u3e ](dtbpy)]PF \u3csub\u3e6\u3c/sub\u3e as the photoredox catalyst. A diverse set of highly functionalized heterocycles proved compatible with the methodology, and moderate to good yields were obtained within 30 minutes of residence time.\u3c/p\u3