Background: Identification of differentially expressed genes from transcriptomic studies is one of the most common mechanisms to identify tumor biomarkers. This approach however is not well suited to identify interaction between genes whose protein products potentially influence each other, which limits its power to identify molecular wiring of tumour cells dictating response to a drug. Due to the fact that signal transduction pathways are not linear and highly interlinked, the biological response they drive may be better described by the relative amount of their components and their functional relationships than by their individual, absolute expression. Results: Gene expression microarray data for 109 tumor cell lines with known sensitivit...
Serra-Musach et al.[Background]: Cancer patients often show no or only modest benefit from a given t...
Background: Cancer patients often show no or only modest benefit from a given therapy. This major pr...
Background: Cancer patients often show no or only modest benefit from a given therapy. This major pr...
Background: Identification of differentially expressed genes from transcriptomic studies is one of t...
TRAIL is a member of the TNF family of cytokines which can selectively induce apoptosis in cancerous...
Co-acting gene networks predict TRAIL responsiveness of tumour cells with high sensitivity than any ...
International audiencePrioritizing genes for their role in drug sensitivity, is an important step in...
International audiencePrioritizing genes for their role in drug sensitivity, is an important step in...
The tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosi...
Background: Cancer patients often show no or only modest benefit from a given therapy. This major pr...
Motivation: Protein-protein interaction (PPI) networks have been shown to successfully predict esse...
In this work an integrated approach was used to identify functional miRNAs regulating gene pathway c...
Background: Cancer patients often show no or only modest benefit from a given therapy. This major pr...
Background: Cancer patients often show no or only modest benefit from a given therapy. This major pr...
In this work an integrated approach was used to identify functional miRNAs regulating gene pathway c...
Serra-Musach et al.[Background]: Cancer patients often show no or only modest benefit from a given t...
Background: Cancer patients often show no or only modest benefit from a given therapy. This major pr...
Background: Cancer patients often show no or only modest benefit from a given therapy. This major pr...
Background: Identification of differentially expressed genes from transcriptomic studies is one of t...
TRAIL is a member of the TNF family of cytokines which can selectively induce apoptosis in cancerous...
Co-acting gene networks predict TRAIL responsiveness of tumour cells with high sensitivity than any ...
International audiencePrioritizing genes for their role in drug sensitivity, is an important step in...
International audiencePrioritizing genes for their role in drug sensitivity, is an important step in...
The tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosi...
Background: Cancer patients often show no or only modest benefit from a given therapy. This major pr...
Motivation: Protein-protein interaction (PPI) networks have been shown to successfully predict esse...
In this work an integrated approach was used to identify functional miRNAs regulating gene pathway c...
Background: Cancer patients often show no or only modest benefit from a given therapy. This major pr...
Background: Cancer patients often show no or only modest benefit from a given therapy. This major pr...
In this work an integrated approach was used to identify functional miRNAs regulating gene pathway c...
Serra-Musach et al.[Background]: Cancer patients often show no or only modest benefit from a given t...
Background: Cancer patients often show no or only modest benefit from a given therapy. This major pr...
Background: Cancer patients often show no or only modest benefit from a given therapy. This major pr...