Add to ORKGCommon characterization techniques used to detect crystallinity in amorphous solid dispersions (ASD) typically have detection or quantification limits on the order of 1%. Herein, an amorphous solid dispersion of indomethacin and polyvinylpyrrolidone/vinyl acetate copolymer produced by hot melt extrusion was determined to be amorphous by powder X-ray diffraction and differential scanning calorimetry. However, through the use of transmission electron microscopy, residual crystals of two populations were identified: single crystals mid-dissolution (<100 nm) and nanocrystalline domains of 5–10 nm in size. Both domain types were observed to contain a high defect density. Polarized light microscopy and scanning electron microscopy techniques supp...
The dissolution of poorly soluble drug molecules into a polymer matrix is a popular oral drug delive...
We seek to further addresss the questions posed by Moseson et al. regarding whether any residual cry...
The preparation of amorphous solid dispersions (ASDs) has enabled the development of oral dosage for...
peer-reviewedCommon characterization techniques used to detect crystallinity in amorphous solid disp...
Amorphous solid dispersions (ASDs) are used to increase the solubility of oral medicines by kinetica...
Amorphous solid dispersions (ASDs) are single-phase amorphous systems, where drug molecules are mole...
It has been estimated that up to 75% of drugs in development exhibit low water solubility. This can ...
The development of a quantitative method determining the crystalline percentage in an amorphous soli...
Purpose: To identify molecular indicators of bulk and surface instabilities of amorphous dispersions...
Purpose To verify the robustness and fundamental value of Atomic Force Microscopy (AFM) and AFM-base...
Newly developed active pharmaceutical ingredients (APIs) are often poorly soluble in water. As a res...
The dissolution or melting of a crystalline drug into a molten polymeric matrix underpins the fabric...
Many drugs today exhibit low water solubility, a major concern for the pharmaceutical industry as it...
The dissolution or melting of a crystalline drug into a molten polymeric matrix underpins the fabric...
Purpose To characterise phase separations in aged hot-melt-extruded solid dispersions at a micron to...
The dissolution of poorly soluble drug molecules into a polymer matrix is a popular oral drug delive...
We seek to further addresss the questions posed by Moseson et al. regarding whether any residual cry...
The preparation of amorphous solid dispersions (ASDs) has enabled the development of oral dosage for...
peer-reviewedCommon characterization techniques used to detect crystallinity in amorphous solid disp...
Amorphous solid dispersions (ASDs) are used to increase the solubility of oral medicines by kinetica...
Amorphous solid dispersions (ASDs) are single-phase amorphous systems, where drug molecules are mole...
It has been estimated that up to 75% of drugs in development exhibit low water solubility. This can ...
The development of a quantitative method determining the crystalline percentage in an amorphous soli...
Purpose: To identify molecular indicators of bulk and surface instabilities of amorphous dispersions...
Purpose To verify the robustness and fundamental value of Atomic Force Microscopy (AFM) and AFM-base...
Newly developed active pharmaceutical ingredients (APIs) are often poorly soluble in water. As a res...
The dissolution or melting of a crystalline drug into a molten polymeric matrix underpins the fabric...
Many drugs today exhibit low water solubility, a major concern for the pharmaceutical industry as it...
The dissolution or melting of a crystalline drug into a molten polymeric matrix underpins the fabric...
Purpose To characterise phase separations in aged hot-melt-extruded solid dispersions at a micron to...
The dissolution of poorly soluble drug molecules into a polymer matrix is a popular oral drug delive...
We seek to further addresss the questions posed by Moseson et al. regarding whether any residual cry...
The preparation of amorphous solid dispersions (ASDs) has enabled the development of oral dosage for...