The goal of our research is to increase our understanding of how biology works at the molecular level, with a particular focus on how enzymes evolve their functions through adaptations to generate new specificities and mechanisms. FunTree (Sillitoe and Furnham, Nucleic Acids Res 44:D317-D323, 2016) is a resource that brings together sequence, structure, phylogenetic, and chemical and mechanistic information for 2340 CATH superfamilies (Sillitoe et al., Nucleic Acids Res 43:D376-D381, 2015) (which all contain at least one enzyme) to allow evolution to be investigated within a structurally defined superfamily.We will give an overview of FunTree's use of sequence and structural alignments to cluster proteins within a superfamily into structura...
The advent of computational approaches to measure functional similarity between enzymes adds a new d...
In this review, we will explore recent computational approaches to understand enzyme evolution from ...
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.Understanding how enzymes...
The goal of our research is to increase our understanding of how biology works at the molecular leve...
FunTree is a new resource that brings together sequence, structure, phylogenetic, chemical and mecha...
In order to understand the evolution of enzyme reactions and to gain an overview of biological catal...
FunTree is a resource that brings together protein sequence, structure and functional information, i...
FunTree is a resource that brings together protein sequence, structure and functional information, i...
<div><p>In order to understand the evolution of enzyme reactions and to gain an overview of biologic...
Studying the evolution of enzymes and their functions improves our ability to determine the function...
Enzymes, as biological catalysts, form the basis of all forms of life. How these proteins have evolv...
The advent of computational approaches to measure functional similarity between enzymes adds a new d...
AbstractEnzymes are the proteins responsible for the catalysis of life. Enzymes sharing a common anc...
In this review, we will explore recent computational approaches to understand enzyme evolution from ...
AbstractEnzymes, as biological catalysts, form the basis of all forms of life. How these proteins ha...
The advent of computational approaches to measure functional similarity between enzymes adds a new d...
In this review, we will explore recent computational approaches to understand enzyme evolution from ...
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.Understanding how enzymes...
The goal of our research is to increase our understanding of how biology works at the molecular leve...
FunTree is a new resource that brings together sequence, structure, phylogenetic, chemical and mecha...
In order to understand the evolution of enzyme reactions and to gain an overview of biological catal...
FunTree is a resource that brings together protein sequence, structure and functional information, i...
FunTree is a resource that brings together protein sequence, structure and functional information, i...
<div><p>In order to understand the evolution of enzyme reactions and to gain an overview of biologic...
Studying the evolution of enzymes and their functions improves our ability to determine the function...
Enzymes, as biological catalysts, form the basis of all forms of life. How these proteins have evolv...
The advent of computational approaches to measure functional similarity between enzymes adds a new d...
AbstractEnzymes are the proteins responsible for the catalysis of life. Enzymes sharing a common anc...
In this review, we will explore recent computational approaches to understand enzyme evolution from ...
AbstractEnzymes, as biological catalysts, form the basis of all forms of life. How these proteins ha...
The advent of computational approaches to measure functional similarity between enzymes adds a new d...
In this review, we will explore recent computational approaches to understand enzyme evolution from ...
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.Understanding how enzymes...