Add to ORKGMultiple sclerosis (MS) is a major cause of disability in young adults. Following an unknown trigger (or triggers), the immune system attacks the myelin sheath surrounding axons, leading to progressive nerve cell death. Antibodies and small-molecule drugs directed against B cells have demonstrated good efficacy in slowing progression of the disease. This review focusses on small-molecule drugs that can affect B-cell biology and may have utility in disease management. The risk genes for MS are examined from the drug target perspective. Existing small-molecule therapies for MS with B-cell actions together with new drugs in development are described. The potential for experimental molecules with B-cell effects is also considered. Small molecul...
Background: The commercially available 10x Genomics protocol to generate droplet-based single-cell R...
Background: Antibiotic resistance in human and animal pathogens is mainly the outcome of human use o...
Background: Antibiotic resistance in human and animal pathogens is mainly the outcome of human use o...
Multiple sclerosis (MS) is a major cause of disability in young adults. Following an unknown trigger...
Traditionally, genetic abnormalities detected by conventional karyotyping, fluorescence in situ hybr...
Background: Primary cell culture using serum free media supplemented with growth factors has been us...
Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors...
Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors...
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease whose pathogenesis can be conc...
Good’s buffers are commonly used for cell culture and, although developed to have minimal to no biol...
Good’s buffers are commonly used for cell culture and, although developed to have minimal to no biol...
Good’s buffers are commonly used for cell culture and, although developed to have minimal to no biol...
Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors...
Good’s buffers are commonly used for cell culture and, although developed to have minimal to no biol...
Background A major cause of disability in secondary progressive multiple sclerosis (SPMS) is progres...
Background: The commercially available 10x Genomics protocol to generate droplet-based single-cell R...
Background: Antibiotic resistance in human and animal pathogens is mainly the outcome of human use o...
Background: Antibiotic resistance in human and animal pathogens is mainly the outcome of human use o...
Multiple sclerosis (MS) is a major cause of disability in young adults. Following an unknown trigger...
Traditionally, genetic abnormalities detected by conventional karyotyping, fluorescence in situ hybr...
Background: Primary cell culture using serum free media supplemented with growth factors has been us...
Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors...
Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors...
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease whose pathogenesis can be conc...
Good’s buffers are commonly used for cell culture and, although developed to have minimal to no biol...
Good’s buffers are commonly used for cell culture and, although developed to have minimal to no biol...
Good’s buffers are commonly used for cell culture and, although developed to have minimal to no biol...
Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors...
Good’s buffers are commonly used for cell culture and, although developed to have minimal to no biol...
Background A major cause of disability in secondary progressive multiple sclerosis (SPMS) is progres...
Background: The commercially available 10x Genomics protocol to generate droplet-based single-cell R...
Background: Antibiotic resistance in human and animal pathogens is mainly the outcome of human use o...
Background: Antibiotic resistance in human and animal pathogens is mainly the outcome of human use o...