Pseudomonas aeruginosa has three type VI secretion systems (T6SSs), H1-, H2-, and H3-T6SS, each belonging to a distinct group. The two T6SS components, TssB/VipA and TssC/VipB, assemble to form tubules that conserve structural/functional homology with tail sheaths of contractile bacteriophages and pyocins. Here, we used cryoelectron microscopy to solve the structure of the H1-T6SS P. aeruginosa TssB1C1 sheath at 3.3 Å resolution. Our structure allowed us to resolve some features of the T6SS sheath that were not resolved in the Vibrio cholerae VipAB and Francisella tularensis IglAB structures. Comparison with sheath structures from other contractile machines, including T4 phage and R-type pyocins, provides a better understanding of how these...
The bacterial type VI secretion system is a multicomponent molecular machine directed against eukary...
The bacterial Type VI secretion system (T6SS) assembles from three major parts: a membrane complex t...
International audienceThe Type VI secretion system (T6SS) is a versatile machine that delivers toxin...
Protein secretion systems in Gram-negative bacteria evolved into a variety of molecular nanomachines...
SummaryType VI secretion systems (T6SSs) are newly identified contractile nanomachines that transloc...
SummaryBacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to del...
The bacterial type VI secretion system (T6SS) uses contraction of a long sheath to quickly thrust a ...
Bacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to deliver ef...
Type VI secretion systems are bacterial virulence-associated nanomachines composed of proteins that ...
The bacterial type VI secretion system (T6SS) uses contraction of a long sheath to quickly thrust a ...
Bacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to deliver ef...
The type VI secretion system (T6SS) is a supra-molecular bacterial complex that resembles phage tail...
Type VI secretion systems (T6SSs) are newly identified contractile nanomachines that translocate eff...
SummaryThe bacterial type VI secretion system is a multicomponent molecular machine directed against...
The type VI secretion systems (T6SS) are present in about a quarter of all Gram-negative bacteria. S...
The bacterial type VI secretion system is a multicomponent molecular machine directed against eukary...
The bacterial Type VI secretion system (T6SS) assembles from three major parts: a membrane complex t...
International audienceThe Type VI secretion system (T6SS) is a versatile machine that delivers toxin...
Protein secretion systems in Gram-negative bacteria evolved into a variety of molecular nanomachines...
SummaryType VI secretion systems (T6SSs) are newly identified contractile nanomachines that transloc...
SummaryBacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to del...
The bacterial type VI secretion system (T6SS) uses contraction of a long sheath to quickly thrust a ...
Bacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to deliver ef...
Type VI secretion systems are bacterial virulence-associated nanomachines composed of proteins that ...
The bacterial type VI secretion system (T6SS) uses contraction of a long sheath to quickly thrust a ...
Bacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to deliver ef...
The type VI secretion system (T6SS) is a supra-molecular bacterial complex that resembles phage tail...
Type VI secretion systems (T6SSs) are newly identified contractile nanomachines that translocate eff...
SummaryThe bacterial type VI secretion system is a multicomponent molecular machine directed against...
The type VI secretion systems (T6SS) are present in about a quarter of all Gram-negative bacteria. S...
The bacterial type VI secretion system is a multicomponent molecular machine directed against eukary...
The bacterial Type VI secretion system (T6SS) assembles from three major parts: a membrane complex t...
International audienceThe Type VI secretion system (T6SS) is a versatile machine that delivers toxin...