Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such as frontotemporal dementia or Alzheimer's disease, atrophy can be observed in key brain structures years before any clinical symptoms are present. Atrophy is most commonly captured as volume change of key structures and the shape changes of these structures are typically not analysed despite being potentially more sensitive than summary volume statistics over the entire structure. In this paper we propose a spatiotemporal analysis pipeline based on Large Diffeomorphic Deformation Metric Mapping (LDDMM) to detect shape changes from volumetric MRI scans. We applied our framework to...
OBJECTIVE: Novel biomarkers for monitoring progression in neurodegenerative conditions are needed. M...
We develop a multivariate analysis of brain anatomy to identify the relevant shape deformation patte...
OBJECTIVE: Novel biomarkers for monitoring progression in neurodegenerative conditions are needed. M...
Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used t...
© 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY licens...
Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used t...
Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used t...
International audienceThe detection of pathological changes in neurodegenerative diseases that occur...
OBJECTIVE: Novel biomarkers for monitoring progression in neurodegenerative conditions are needed. M...
We develop a multivariate analysis of brain anatomy to identify the relevant shape deformation patte...
OBJECTIVE: Novel biomarkers for monitoring progression in neurodegenerative conditions are needed. M...
Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used t...
© 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY licens...
Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used t...
Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used t...
International audienceThe detection of pathological changes in neurodegenerative diseases that occur...
OBJECTIVE: Novel biomarkers for monitoring progression in neurodegenerative conditions are needed. M...
We develop a multivariate analysis of brain anatomy to identify the relevant shape deformation patte...
OBJECTIVE: Novel biomarkers for monitoring progression in neurodegenerative conditions are needed. M...