Add to ORKGNovel detrimental functions of senescent cells have been recently uncovered in the context of cancer development and progression, which they mainly exert through the secretion of several pro-tumorigenic factors. Here we discuss how cellular senescence and its secretory phenotype can be involved in the widely unexplored phenomenon of paracrine tumorigenesis
Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-cycle arre...
Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation o...
In addition to promoting various forms of cell death, most conventional anti-tumor therapies also pr...
Cellular senescence is a process that can prevent tumour development in a cell autonomous manner by ...
Senescent cells may promote tumour progression through the activation of a senescence-associated sec...
Over recent decades, the field of cellular senescence has attracted considerable attention due to i...
Cellular senescence has mainly been associated with tumor suppression and aging, mediated through ce...
Cellular senescence occurs in proliferating cells as a consequence of various triggers including tel...
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in r...
During the last years, progress has been made on the identification of mechanisms involved in anteri...
Cellular senescence is a state of stable, terminal cell cycle arrest associated with various macromo...
Cellular senescence describes an irreversible growth arrest characterized by distinct morphology, ge...
Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a com...
Over recent decades, the field of cellular senescence has attracted considerable attention due to it...
Several cancer interventions induce DNA damage and promote senescence in cancer and nonmalignant cel...
Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-cycle arre...
Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation o...
In addition to promoting various forms of cell death, most conventional anti-tumor therapies also pr...
Cellular senescence is a process that can prevent tumour development in a cell autonomous manner by ...
Senescent cells may promote tumour progression through the activation of a senescence-associated sec...
Over recent decades, the field of cellular senescence has attracted considerable attention due to i...
Cellular senescence has mainly been associated with tumor suppression and aging, mediated through ce...
Cellular senescence occurs in proliferating cells as a consequence of various triggers including tel...
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in r...
During the last years, progress has been made on the identification of mechanisms involved in anteri...
Cellular senescence is a state of stable, terminal cell cycle arrest associated with various macromo...
Cellular senescence describes an irreversible growth arrest characterized by distinct morphology, ge...
Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a com...
Over recent decades, the field of cellular senescence has attracted considerable attention due to it...
Several cancer interventions induce DNA damage and promote senescence in cancer and nonmalignant cel...
Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-cycle arre...
Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation o...
In addition to promoting various forms of cell death, most conventional anti-tumor therapies also pr...