Metabolic profiling of plasma from discordant schizophrenia twins:Correlation between lipid signals and global functioning in female schizophrenia patients

Tsang, Tsz M.
Huang, Jeffrey T.J.
Holmes, Elaine
Bahn, Sabine

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Publication date

April 2006

DOI

10.1021/pr0503782

ISSN

1535-3893

Citation count (estimate)

Abstract

1H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8 pairs of age-matched healthy twins in an effort to disentangle genetic and epigenetic components of schizophrenia. We identified alterations in the lipid profile of both affected and unaffected schizophrenia twins. Additionally, there is a close association of VLDL/LDL signals and Global Functioning Scores in female twins suffering from schizophrenia. Our results further support a link between metabolic disturbances and the etiopathology of schizophrenia.</p