GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

Blockade of MGMT Expression by O-6 Benzyl Guanine Leads to Inhibition of Pancreatic Cancer Growth and Induction of Apoptosis

January 2009

Purpose: We sought to determine whether administration of a MGMT blocker, O-6-benzyl guanine (O(6)BG...

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma

Cook, N
Basu, B
Smith, D-M
Gopinathan, A
Evans, J
Steward, WP
Palmer, D
Propper, D
Venugopal, B
Hategan, M
Anthoney, DA
Hampson, LV
Nebozhyn, M
Tuveson, D
Farmer-Hall, H
Turner, H
McLeod, R
Halford, S
Jodrell, D

March 2018

Background: The Notch pathway is frequently activated in cancer. Pathway inhibition by γ-secretase i...

The pharmacology of GPR55 and its potential role in cancer

Ford, Lesley

January 2009

In a recent patent, GPR55 emerged as a novel target for cannabinoid modulation, and was found to be ...

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

Ferro, R.
Adamska, A.
Lattanzio, R.
Mavrommati, I.
Edling, C.
Arifin, S.
Fyffe, C.
Sala, G.
Sacchetto, L.
Chiorino, G.
De Laurenzi, V.
Piantelli, M.
Sansom, O.
Maffucci, T.
Falasca, Marco

January 2018

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

Ferro, R.
Adamska, A.
Lattanzio, R.
Mavrommati, I.
Edling, C.E.
Arifin, S.A.
Fyffe, C.A.
Sala, G.
Sacchetto, L.
Chiorino, G.
De Laurenzi, V.
Piantelli, M.
Sansom, O.J.
Maffucci, T.
Falasca, M.

January 2018

The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 ye...

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

Ferro, R.
Adamska, A.
Lattanzio, R.
Mavrommati, I.
Edling, C.E.
Arifin, S.A.
Fyffe, C.A.
Sala, G.
Sacchetto, L.
Chiorino, G.
De Laurenzi, V.
Piantelli, M.
Sansom, O.J.
Maffucci, T.
Falasca, M.

January 2018

The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 ye...

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

Ferro, Riccardo
Adamska, Aleksandra
Lattanzio, Rossano
Mavrommati, Ioanna
Edling, Charlotte E.
Ahmad Arifin, Syamsul
Fyffe, Chanse A.
Sala, Gianluca
Sacchetto, L.
Chiorino, Giovanna
De Laurenzi, Vincenzo
Piantelli, Mauro
Sansom, Owen
Maffucci, Tania
Falasca, Marco

July 2018

The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 ye...

Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases

Yeo, D
Nhi, H
Beutler, JA
Christophi, C
Shulkes, A
Baldwin, GS
Nikfarjam, M
He, H

May 2014

The fulltext of this publication will be made publicly available after relevant embargo periods have...

Systematic study of GPRC5A in the context of pancreatic ductal adenocarcinoma

Zhou, Honglei

January 2016

The G protein-coupled receptor, class C, group 5, member A (GPRC5A), also known as Retinoic acid-ind...

Systematic study of GPRC5A in the context of pancreatic ductal adenocarcinoma

Zhou, Honglei

January 2016

The G protein-coupled receptor, class C, group 5, member A (GPRC5A), also known as Retinoic acid-ind...

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

Cook, N.
Frese, K. K.
Bapiro, T. E.
Jacobetz, M. A.
Gopinathan, A.
Miller, J. L.
Rao, S. S.
Demuth, T.
Howat, W. J.
Jodrell, D. I.
Tuveson, D. A.

March 2012

Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease that is refractory to medical inte...

ABC transporters and G protein-coupled receptors: perspectives for novel anti-cancer drugs

Adamska, Aleksandra

January 2019

Pancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease with high mortality rates and l...

Local Delivery of Gemcitabine Inhibits Pancreatic and Cholangiocarcinoma Tumor Growth by Promoting Epidermal Growth Factor Receptor Degradation

이동기
장성일
황성순

January 2020

Gemcitabine is clinically used to treat certain types of cancers, including pancreatic and biliary c...

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma

Cook, Natalie
Basu, Bristi
Smith, Donna-Michelle
Gopinathan, Aarthi
Evans, T.R. Jeffry
Steward, William P.
Palmer, Dan
Propper, David
Venugopal, Balaji
Hategan, Mirela
Anthoney, D. Alan
Hampson, Lisa V.
Nebozhyn, Michael
Tuveson, Dave
Farmer-Hall, Hayley
Turner, Helen
McLeod, Robert
Halford, Sarah
Jodrell, Duncan

March 2018

Background: The Notch pathway is frequently activated in cancer. Pathway inhibition by γ-secretase ...

MicroRNA Profiling Implies New Markers of Gemcitabine Chemoresistance in Mutant p53 Pancreatic Ductal Adenocarcinoma

Dhayat, S. (Sameer)
Mardin, W.A.M. (Wolf)
Seggewiß, J. (Jochen)
Ströse, A.J. (Anda)
Matuszcak, C. (Christiane)
Hummel, R. (Richard)
Senninger, N. (Norbert)
Mees, S.T. (Sören)
Haier, J. (Jörg)

April 2016

Background: No reliable predictors of susceptibility to gemcitabine chemotherapy exist in pancreatic...

Blockade of MGMT Expression by O-6 Benzyl Guanine Leads to Inhibition of Pancreatic Cancer Growth and Induction of Apoptosis

January 2009

Purpose: We sought to determine whether administration of a MGMT blocker, O-6-benzyl guanine (O(6)BG...

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma

Cook, N
Basu, B
Smith, D-M
Gopinathan, A
Evans, J
Steward, WP
Palmer, D
Propper, D
Venugopal, B
Hategan, M
Anthoney, DA
Hampson, LV
Nebozhyn, M
Tuveson, D
Farmer-Hall, H
Turner, H
McLeod, R
Halford, S
Jodrell, D

March 2018

Background: The Notch pathway is frequently activated in cancer. Pathway inhibition by γ-secretase i...

The pharmacology of GPR55 and its potential role in cancer

Ford, Lesley

January 2009

In a recent patent, GPR55 emerged as a novel target for cannabinoid modulation, and was found to be ...

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

Ferro, R.
Adamska, A.
Lattanzio, R.
Mavrommati, I.
Edling, C.
Arifin, S.
Fyffe, C.
Sala, G.
Sacchetto, L.
Chiorino, G.
De Laurenzi, V.
Piantelli, M.
Sansom, O.
Maffucci, T.
Falasca, Marco

January 2018

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

Ferro, R.
Adamska, A.
Lattanzio, R.
Mavrommati, I.
Edling, C.E.
Arifin, S.A.
Fyffe, C.A.
Sala, G.
Sacchetto, L.
Chiorino, G.
De Laurenzi, V.
Piantelli, M.
Sansom, O.J.
Maffucci, T.
Falasca, M.

January 2018

The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 ye...

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

Ferro, R.
Adamska, A.
Lattanzio, R.
Mavrommati, I.
Edling, C.E.
Arifin, S.A.
Fyffe, C.A.
Sala, G.
Sacchetto, L.
Chiorino, G.
De Laurenzi, V.
Piantelli, M.
Sansom, O.J.
Maffucci, T.
Falasca, M.

January 2018

The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 ye...

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

Ferro, Riccardo
Adamska, Aleksandra
Lattanzio, Rossano
Mavrommati, Ioanna
Edling, Charlotte E.
Ahmad Arifin, Syamsul
Fyffe, Chanse A.
Sala, Gianluca
Sacchetto, L.
Chiorino, Giovanna
De Laurenzi, Vincenzo
Piantelli, Mauro
Sansom, Owen
Maffucci, Tania
Falasca, Marco

July 2018

The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 ye...

Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases

Yeo, D
Nhi, H
Beutler, JA
Christophi, C
Shulkes, A
Baldwin, GS
Nikfarjam, M
He, H

May 2014

The fulltext of this publication will be made publicly available after relevant embargo periods have...

Systematic study of GPRC5A in the context of pancreatic ductal adenocarcinoma

Zhou, Honglei

January 2016

The G protein-coupled receptor, class C, group 5, member A (GPRC5A), also known as Retinoic acid-ind...

Systematic study of GPRC5A in the context of pancreatic ductal adenocarcinoma

Zhou, Honglei

January 2016

The G protein-coupled receptor, class C, group 5, member A (GPRC5A), also known as Retinoic acid-ind...

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

Cook, N.
Frese, K. K.
Bapiro, T. E.
Jacobetz, M. A.
Gopinathan, A.
Miller, J. L.
Rao, S. S.
Demuth, T.
Howat, W. J.
Jodrell, D. I.
Tuveson, D. A.

March 2012

Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease that is refractory to medical inte...

ABC transporters and G protein-coupled receptors: perspectives for novel anti-cancer drugs

Adamska, Aleksandra

January 2019

Pancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease with high mortality rates and l...

Local Delivery of Gemcitabine Inhibits Pancreatic and Cholangiocarcinoma Tumor Growth by Promoting Epidermal Growth Factor Receptor Degradation

이동기
장성일
황성순

January 2020

Gemcitabine is clinically used to treat certain types of cancers, including pancreatic and biliary c...

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma

Cook, Natalie
Basu, Bristi
Smith, Donna-Michelle
Gopinathan, Aarthi
Evans, T.R. Jeffry
Steward, William P.
Palmer, Dan
Propper, David
Venugopal, Balaji
Hategan, Mirela
Anthoney, D. Alan
Hampson, Lisa V.
Nebozhyn, Michael
Tuveson, Dave
Farmer-Hall, Hayley
Turner, Helen
McLeod, Robert
Halford, Sarah
Jodrell, Duncan

March 2018

Background: The Notch pathway is frequently activated in cancer. Pathway inhibition by γ-secretase ...

MicroRNA Profiling Implies New Markers of Gemcitabine Chemoresistance in Mutant p53 Pancreatic Ductal Adenocarcinoma

Dhayat, S. (Sameer)
Mardin, W.A.M. (Wolf)
Seggewiß, J. (Jochen)
Ströse, A.J. (Anda)
Matuszcak, C. (Christiane)
Hummel, R. (Richard)
Senninger, N. (Norbert)
Mees, S.T. (Sören)
Haier, J. (Jörg)

April 2016

Background: No reliable predictors of susceptibility to gemcitabine chemotherapy exist in pancreatic...

Blockade of MGMT Expression by O-6 Benzyl Guanine Leads to Inhibition of Pancreatic Cancer Growth and Induction of Apoptosis

January 2009

Purpose: We sought to determine whether administration of a MGMT blocker, O-6-benzyl guanine (O(6)BG...

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma

Cook, N
Basu, B
Smith, D-M
Gopinathan, A
Evans, J
Steward, WP
Palmer, D
Propper, D
Venugopal, B
Hategan, M
Anthoney, DA
Hampson, LV
Nebozhyn, M
Tuveson, D
Farmer-Hall, H
Turner, H
McLeod, R
Halford, S
Jodrell, D

March 2018

Background: The Notch pathway is frequently activated in cancer. Pathway inhibition by γ-secretase i...

The pharmacology of GPR55 and its potential role in cancer

Ford, Lesley

January 2009

In a recent patent, GPR55 emerged as a novel target for cannabinoid modulation, and was found to be ...

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

Abstract

Extracted data

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

Abstract

Extracted data

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