Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study

Empagliflozin on top of metformin treatment improves arterial function in patients with type 1 diabetes mellitus

Mojca Lunder
Miodrag Janić
Miha Japelj
Andrej Juretič
Andrej Janež
Mišo Šabovič

December 2018

Abstract Background Deteriorated arterial function and high incidence of cardiovascular events chara...

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial.

Petrie, J R [et al]
REMOVAL Study Group inc. collaboration from:
Shore, Angela
Miller, C.
Warren, Roderick

June 2017

RD&E were one of the study sites for this project.Metformin might reduce insulin requirement and imp...

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL) : a double-blind, randomised, placebo-controlled trial

Petrie, John R.
Chaturvedi, Nishi
Ford, Ian
Brouwers, Martijn C. G. J.
Greenlaw, Nicola
Tillin, Therese
Hramiak, Irene
Hughes, Alun D.
Jenkins, Alicia J.
Klein, Barbara E K
Klein, Ronald
Ooi, Teik C.
Rossing, Peter
Stehouwer, Coen D. A.
Sattar, Naveed
Colhoun, Helen M.
Nickerson, H.
Lou, O.
Dutta, S.
Haw, J.
Anderson, C.
Kean, S.
Thomson, E.
Gillespie, L.
Gibb, J.
Greenlaw, N.
Keech, Anthony C.
Jenkins, Mark A.
March, K.
Williams, S.
Coady, E.
Bots, M.
Dreyer, J.
Jan, T.
Sheffy, K.
Lusky, R.
Peleg, S.
Shore, A.
Carty, D.
Donnan, P.
Witham, M.
Adler, A..
Lonn, E
Rauchhaus, P.
Lindsay, R.W.
Brouwers, M.
Van-Melckebeke, J.
Gillespie, L.
Hamill, T.
Cuthbertson, L.

August 2017

Background Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 ...

Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study.

Pitocco, Dario (ORCID:0000-0002-6220-686X)
Zaccardi, Francesco
Tarzia, Pierpaolo
Milo, Maria
Scavone, Giuseppe
Rizzo, P
Pagliaccia, Francesca
Nerla, Roberto
Di Franco, A
Manto, A
Rocca, Bianca (ORCID:0000-0001-8304-6423)
Lanza, Gaetano Antonio (ORCID:0000-0003-2187-6653)
Crea, Filippo (ORCID:0000-0001-9404-8846)
Ghirlanda, Giovanni

January 2012

AIMS: Several studies have investigated the effects of metformin treatment in patients with type ...

Improved endothelial function with metformin in type 2 diabetes mellitus

Mather, Kieren J
Verma, Subodh
Anderson, Todd J

April 2001

AbstractOBJECTIVESThis study was designed to assess the effect of metformin on impaired endothelial ...

Long-term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial

de Jager, J.
Kooy, A.
Schalkwijk, C.
van der Kolk, J.
Lehert, Philippe
Bets, D.
Wulffelé, M. G.
Donker, A. J.
Stehouwer, C. D. A.

January 2014

Objectives We investigated whether metformin can improve endothelial function and decrease inflammat...

First results on the Effects of metformin on endothelial function and inflammatory activity in type 2 diabetes mellitus: the HOME study, a randomized placebo-controlled trial

De Jager, J
Stehouwer, C
Donker, A
Teerlink, T
Schalkwijk, CG
Wulffelé, D
Bets, D.
Lehert, Philippe
Kooy, A
Klinische Endocrinologiedagen

January 2004

From the Study HOME, the first results on the Effects of metformin on endothelial function and infla...

Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized placebo-controlled trial

De Jager, J
Stehouwer, C
Donker, A
Teerlink, T
Schalkwijk, T
Wulffelé, MG
Bets, D.
Lehert, Philippe
Kooy, A
Annual congress of the American Diabetes Association,

January 2004

The Effects of short-term treatment with metformin on markers of endothelial function and inflammato...

Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial

Jager, J
Stehouwer, C
Donker, A
Bets, D.
Lehert, Philippe
Kooy, A

January 2005

metformin may improve endothelial function and chronic, low-grade inflammation. All patients were ra...

New results in the study of Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized placebo-controlled trial

De Jager, J
Stehouwer, C
Donker, A
Teerlink, T
Schalkwijk, CG
Wulffelé, D
Bets, D.
Lehert, Philippe
Kooy, A
Nationaal Congress Internistendagen

January 2004

The Effects of short-term treatment with metformin on markers of endothelial function and inflammato...

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL):a double-blind, randomised, placebo-controlled trial

Petrie, John R.
Chaturvedi, Nishi
Ford, Ian
Brouwers, Martijn C. G. J.
Greenlaw, Nicola
Tillin, Therese
Hramiak, Irene
Hughes, Alun D.
Jenkins, Alicia J.
Klein, Barbara E. K.
Klein, Ronald
Ooi, Teik C.
Rossing, Peter
Stehouwer, Coen D. A.
Sattar, Naveed
Colhoun, Helen M.

August 2017

Background Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 ...

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial

Petrie, John R.
Chaturvedi, Nishi
Ford, Ian
Brouwers, Martijn C. G. J.
Greenlaw, Nicola
Tillin, Therese
Hramiak, Irene
Hughes, Alun D.
Jenkins, Alicia J.
Klein, Barbara E. K.
Klein, Ronald
Ooi, Teik C.
Rossing, Peter
Stehouwer, Coen D. A.
Sattar, Naveed
Colhoun, Helen M.

August 2017

Background Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 ...

Metformin Improves Endothelial Function and Reduces Blood Pressure in Diabetic Spontaneously Hypertensive Rats Independent from Glycemia Control: Comparison to Vildagliptin

Hamidi Shishavan, Mahdi
Henning, Robert H
van Buiten, Azuwerus
Goris, Maaike
Deelman, Leo E
Buikema, Hendrik

September 2017

Metformin confers vascular benefits beyond glycemia control, possibly via pleiotropic effects on end...

Empagliflozin on top of metformin treatment improves arterial function in patients with type 1 diabetes mellitus

Mojca Lunder
Miodrag Janić
Miha Japelj
Andrej Juretič
Andrej Janež
Mišo Šabovič

December 2018

Abstract Background Deteriorated arterial function and high incidence of cardiovascular events chara...

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial.

Petrie, J R [et al]
REMOVAL Study Group inc. collaboration from:
Shore, Angela
Miller, C.
Warren, Roderick

June 2017

RD&E were one of the study sites for this project.Metformin might reduce insulin requirement and imp...

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL) : a double-blind, randomised, placebo-controlled trial

Petrie, John R.
Chaturvedi, Nishi
Ford, Ian
Brouwers, Martijn C. G. J.
Greenlaw, Nicola
Tillin, Therese
Hramiak, Irene
Hughes, Alun D.
Jenkins, Alicia J.
Klein, Barbara E K
Klein, Ronald
Ooi, Teik C.
Rossing, Peter
Stehouwer, Coen D. A.
Sattar, Naveed
Colhoun, Helen M.
Nickerson, H.
Lou, O.
Dutta, S.
Haw, J.
Anderson, C.
Kean, S.
Thomson, E.
Gillespie, L.
Gibb, J.
Greenlaw, N.
Keech, Anthony C.
Jenkins, Mark A.
March, K.
Williams, S.
Coady, E.
Bots, M.
Dreyer, J.
Jan, T.
Sheffy, K.
Lusky, R.
Peleg, S.
Shore, A.
Carty, D.
Donnan, P.
Witham, M.
Adler, A..
Lonn, E
Rauchhaus, P.
Lindsay, R.W.
Brouwers, M.
Van-Melckebeke, J.
Gillespie, L.
Hamill, T.
Cuthbertson, L.

August 2017

Background Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 ...

Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study.

Pitocco, Dario (ORCID:0000-0002-6220-686X)
Zaccardi, Francesco
Tarzia, Pierpaolo
Milo, Maria
Scavone, Giuseppe
Rizzo, P
Pagliaccia, Francesca
Nerla, Roberto
Di Franco, A
Manto, A
Rocca, Bianca (ORCID:0000-0001-8304-6423)
Lanza, Gaetano Antonio (ORCID:0000-0003-2187-6653)
Crea, Filippo (ORCID:0000-0001-9404-8846)
Ghirlanda, Giovanni

January 2012

AIMS: Several studies have investigated the effects of metformin treatment in patients with type ...

Improved endothelial function with metformin in type 2 diabetes mellitus

Mather, Kieren J
Verma, Subodh
Anderson, Todd J

April 2001

AbstractOBJECTIVESThis study was designed to assess the effect of metformin on impaired endothelial ...

Long-term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial

de Jager, J.
Kooy, A.
Schalkwijk, C.
van der Kolk, J.
Lehert, Philippe
Bets, D.
Wulffelé, M. G.
Donker, A. J.
Stehouwer, C. D. A.

January 2014

Objectives We investigated whether metformin can improve endothelial function and decrease inflammat...

First results on the Effects of metformin on endothelial function and inflammatory activity in type 2 diabetes mellitus: the HOME study, a randomized placebo-controlled trial

De Jager, J
Stehouwer, C
Donker, A
Teerlink, T
Schalkwijk, CG
Wulffelé, D
Bets, D.
Lehert, Philippe
Kooy, A
Klinische Endocrinologiedagen

January 2004

From the Study HOME, the first results on the Effects of metformin on endothelial function and infla...

Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized placebo-controlled trial

De Jager, J
Stehouwer, C
Donker, A
Teerlink, T
Schalkwijk, T
Wulffelé, MG
Bets, D.
Lehert, Philippe
Kooy, A
Annual congress of the American Diabetes Association,

January 2004

The Effects of short-term treatment with metformin on markers of endothelial function and inflammato...

Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial

Jager, J
Stehouwer, C
Donker, A
Bets, D.
Lehert, Philippe
Kooy, A

January 2005

metformin may improve endothelial function and chronic, low-grade inflammation. All patients were ra...

New results in the study of Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized placebo-controlled trial

De Jager, J
Stehouwer, C
Donker, A
Teerlink, T
Schalkwijk, CG
Wulffelé, D
Bets, D.
Lehert, Philippe
Kooy, A
Nationaal Congress Internistendagen

January 2004

The Effects of short-term treatment with metformin on markers of endothelial function and inflammato...

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL):a double-blind, randomised, placebo-controlled trial

Petrie, John R.
Chaturvedi, Nishi
Ford, Ian
Brouwers, Martijn C. G. J.
Greenlaw, Nicola
Tillin, Therese
Hramiak, Irene
Hughes, Alun D.
Jenkins, Alicia J.
Klein, Barbara E. K.
Klein, Ronald
Ooi, Teik C.
Rossing, Peter
Stehouwer, Coen D. A.
Sattar, Naveed
Colhoun, Helen M.

August 2017

Background Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 ...

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial

Petrie, John R.
Chaturvedi, Nishi
Ford, Ian
Brouwers, Martijn C. G. J.
Greenlaw, Nicola
Tillin, Therese
Hramiak, Irene
Hughes, Alun D.
Jenkins, Alicia J.
Klein, Barbara E. K.
Klein, Ronald
Ooi, Teik C.
Rossing, Peter
Stehouwer, Coen D. A.
Sattar, Naveed
Colhoun, Helen M.

August 2017

Background Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 ...

Metformin Improves Endothelial Function and Reduces Blood Pressure in Diabetic Spontaneously Hypertensive Rats Independent from Glycemia Control: Comparison to Vildagliptin

Hamidi Shishavan, Mahdi
Henning, Robert H
van Buiten, Azuwerus
Goris, Maaike
Deelman, Leo E
Buikema, Hendrik

September 2017

Metformin confers vascular benefits beyond glycemia control, possibly via pleiotropic effects on end...

Empagliflozin on top of metformin treatment improves arterial function in patients with type 1 diabetes mellitus

Mojca Lunder
Miodrag Janić
Miha Japelj
Andrej Juretič
Andrej Janež
Mišo Šabovič

December 2018

Abstract Background Deteriorated arterial function and high incidence of cardiovascular events chara...

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial.

Petrie, J R [et al]
REMOVAL Study Group inc. collaboration from:
Shore, Angela
Miller, C.
Warren, Roderick

June 2017

RD&E were one of the study sites for this project.Metformin might reduce insulin requirement and imp...

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL) : a double-blind, randomised, placebo-controlled trial

Petrie, John R.
Chaturvedi, Nishi
Ford, Ian
Brouwers, Martijn C. G. J.
Greenlaw, Nicola
Tillin, Therese
Hramiak, Irene
Hughes, Alun D.
Jenkins, Alicia J.
Klein, Barbara E K
Klein, Ronald
Ooi, Teik C.
Rossing, Peter
Stehouwer, Coen D. A.
Sattar, Naveed
Colhoun, Helen M.
Nickerson, H.
Lou, O.
Dutta, S.
Haw, J.
Anderson, C.
Kean, S.
Thomson, E.
Gillespie, L.
Gibb, J.
Greenlaw, N.
Keech, Anthony C.
Jenkins, Mark A.
March, K.
Williams, S.
Coady, E.
Bots, M.
Dreyer, J.
Jan, T.
Sheffy, K.
Lusky, R.
Peleg, S.
Shore, A.
Carty, D.
Donnan, P.
Witham, M.
Adler, A..
Lonn, E
Rauchhaus, P.
Lindsay, R.W.
Brouwers, M.
Van-Melckebeke, J.
Gillespie, L.
Hamill, T.
Cuthbertson, L.

August 2017

Background Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 ...

Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study

Abstract

Extracted data

Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo-controlled randomized study

Abstract

Extracted data

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