During dermal injury and inflammation the serine proteases kallikreins cleave endogenous, multifunctional substrates (kininogens) to form bradykinin and kallidin. The actions of kinins are mediated by preferential binding to constitutively expressed kinin-B2 receptors or inducible kinin-B1 receptors. A feature of the kinin-B1 receptors is that they show low levels of expression, but are distinctly upregulated following tissue injury and inflammation. Because recent evidence suggested that kinin-B1 receptors may perform a protective role during inflammation, we investigated the specific occurrence of the kallikrein-kinin components in skin biopsies obtained from normal skin, patients undergoing surgery, basalioma, lichenificated atopic eczem...
Peptide and non-peptide kinin receptor antagonists were evaluated in cutaneous inflammation models i...
Background: Kinins are released during dermal injury and inflammation and seem to contribute to the ...
AbstractHuman tissue prokallikrein, a zymogen of the kallikrein-kinin system, circulates in plasma b...
During dermal injury and inflammation the serine proteases kallikreins cleave endogenous, multifunct...
Background: Wound healing is a complex and dynamic process that includes 3 different phases: inflamm...
Thesis (M.Med.)-University of Natal, 1996.Inflammation is the normal biological response to tissue i...
Kinins are key pro-inflammatory peptides that exhibit mitogenic effects in tissue-specific cellular ...
BACKGROUND AND PURPOSE: Evidence indicates that the entire kallikrein‐kinin system is present in the...
Human psoriatic scale extracts produced kinins from heated plasma (11.3 ± 5.5ng kinin/mg protein) an...
The discovery of the kinin system is not recent, but its study in clinical field has been done only ...
Kinins, such as bradykinin and kallidin, are peptides generated from kininogen precursor proteins by...
Melanoma is a very aggressive tumor that arises from melanocytes. Late stage and widely spread disea...
Abstract: Kinins are biologically active peptides that are powerful mediators of cellular inflammati...
Evidence is accumulating that the pathogenesis of many diseases is triggered by inappropriate inflam...
International audienceImpaired skin wound healing is a major medical problem in diabetic subjects. K...
Peptide and non-peptide kinin receptor antagonists were evaluated in cutaneous inflammation models i...
Background: Kinins are released during dermal injury and inflammation and seem to contribute to the ...
AbstractHuman tissue prokallikrein, a zymogen of the kallikrein-kinin system, circulates in plasma b...
During dermal injury and inflammation the serine proteases kallikreins cleave endogenous, multifunct...
Background: Wound healing is a complex and dynamic process that includes 3 different phases: inflamm...
Thesis (M.Med.)-University of Natal, 1996.Inflammation is the normal biological response to tissue i...
Kinins are key pro-inflammatory peptides that exhibit mitogenic effects in tissue-specific cellular ...
BACKGROUND AND PURPOSE: Evidence indicates that the entire kallikrein‐kinin system is present in the...
Human psoriatic scale extracts produced kinins from heated plasma (11.3 ± 5.5ng kinin/mg protein) an...
The discovery of the kinin system is not recent, but its study in clinical field has been done only ...
Kinins, such as bradykinin and kallidin, are peptides generated from kininogen precursor proteins by...
Melanoma is a very aggressive tumor that arises from melanocytes. Late stage and widely spread disea...
Abstract: Kinins are biologically active peptides that are powerful mediators of cellular inflammati...
Evidence is accumulating that the pathogenesis of many diseases is triggered by inappropriate inflam...
International audienceImpaired skin wound healing is a major medical problem in diabetic subjects. K...
Peptide and non-peptide kinin receptor antagonists were evaluated in cutaneous inflammation models i...
Background: Kinins are released during dermal injury and inflammation and seem to contribute to the ...
AbstractHuman tissue prokallikrein, a zymogen of the kallikrein-kinin system, circulates in plasma b...