Decreased ligand affinity rather than glucocorticoid receptor down-regulation in patients with endogenous Cushing's syndrome

Negative Feedback Regulation following Administration of Chronic Exogenous Corticosterone

Young, Elizabeth A.
Kwak, Seung P.
Kottak, Juliet

January 1995

Administration of exogenous glucocorticoids is known to suppress the HPA axis and has been reported ...

Impact of glucocorticoid receptor density on ligand-independent dimerization, cooperative ligand-binding and basal priming of transactivation: a cell culture model

Robertson, Steven
Rohwer, Johann M
Hapgood, Janet P
Louw, Ann

January 2013

Glucocorticoid receptor (GR) levels vary between tissues and individuals and are altered by physiolo...

Five patients with biochemical and/or clinical generalized glucocorticoid resistance without alterations in the glucocorticoid receptor gene

Huizenga, Nannette
Lange, Pieter
Koper, Jan
Herder, Wouter
Abs, R.
Kasteren, J.H.
Jong, Frank
Lamberts, Steven

January 2000

textabstractCortisol resistance (CR) is a rare disease characterized by a generalized red...

Decreased ligand affinity rather than glucocorticoid receptor down-regulation in patients with endogenous Cushing's syndrome

Huizenga N.A.T.M.
De Herder W.W.
Koper J.W.
De Lange P.
Lely A.J.V.D.
Brinkmann A.O.
De Jong F.H.
Lamberts S.W.J.

January 2000

Objective: Glucocorticoids (GCs) serve a variety of important functions throughout the body. The syn...

Molecular Mechanisms of Glucocorticoid Resistance in Corticotropinomas: New Developments and Drug Targets

Ciato, Denis
Albani, Adriana

January 2020

Cushing's disease is characterized by excessive adrenocorticotropin hormone (ACTH) secretion caused ...

Expression of the human glucocorticoid receptor splice variants α, β, and P in peripheral blood mononuclear leukocytes in healthy controls and in patients with hyper- and hypocortisolism

Hagendorf, A.
Koper, J.W. (Jan)
Jong, F.H. (Frank) de
Brinkmann, A.O. (Albert)
Lamberts, S.W.J. (Steven)
Feelders, R.A. (Richard)

November 2005

Context: The effects of cortisol are mediated by the α-isoform of the glucocorticoid receptor (GR). ...

Treatment with synthetic glucocorticoids and the hypothalamus-pituitary-adrenal axis

Paragliola, Rosa Maria (ORCID:0000-0002-5070-7771)
Papi, Giampaolo
Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865)
Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274)

January 2017

Chronic glucocorticoid (GC) treatment represents a widely-prescribed therapy for several diseases in...

Peripheral glucocorticoid receptor antagonism by relacorilant with modest HPA axis disinhibition

Viho, Eva M.G.
Kroon, Jan
Feelders, Richard A.
Houtman, René
van den Dungen, Elisabeth S.R.
Pereira, Alberto M.
Hunt, Hazel J.
Hofland, Leo J.
Meijer, Onno C.

February 2023

Glucocorticoid stress hormones are produced in response to hypothalamic-pituitary-adrenal (HPA) axis...

Contribution of Glucocorticoids and Glucocorticoid Receptors to the Regulation of Neurodegenerative Processes

Vyas, Sheela
Maatouk, Layal

December 2013

International audienceIsolation of glucocorticoids (GCs) from adrenal glands followed by synthesis l...

Pre-receptor Regulation of Cortisol in Hypothalamic-Pituitary-Adrenal Axis Functioning an Metabolism

Dekker, Marieke

January 2011

textabstractGlucocorticoids (GCs) are ubiquitous, nuclear hormones, which are essential for life. In...

Glucocorticoids are active players and therapeutic targets in atherosclerotic cardiovascular disease

Sluis, R.J. van der
Hoekstra, M.

January 2020

Adrenal-derived glucocorticoids mediate the physiological response to stress. Chronic disturbances i...

The Role of Glucocorticoid Receptor in the Pathophysiology of Pituitary Corticotroph Adenomas

Regazzo, Daniela
Mondin, Alessandro
Scaroni, Carla
Occhi, Gianluca
Barbot, Mattia

January 2022

Adrenocorticotropic Hormone (ACTH)-secreting pituitary adenomas are rare tumors characterized by aut...

Human glucocorticoid receptor cDNA contains sequences sufficient for receptor down-regulation.

Burnstein, K L
Jewell, C M
Cidlowski, J A

January 1990

Glucocorticoid receptors are ligand-dependent transcription factors that are subject to down-regulat...

The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity

Koorneef, L.L.
Kroon, J.
Viho, E.M.G.
Wahl, L.F.
Heckmans, K.M.L.
Dorst, M.M.A.R. van
Hoekstra, M.
Houtman, R.
Hunt, H.
Meijer, O.C.

July 2020

Glucocorticoids mediate numerous essential processes in the human body via binding to the glucocorti...

Treatment with Synthetic Glucocorticoids and the Hypothalamus-Pituitary-Adrenal Axis

Rosa Maria Paragliola

October 2017

Chronic glucocorticoid (GC) treatment represents a widely-prescribed therapy for several diseases in...

Negative Feedback Regulation following Administration of Chronic Exogenous Corticosterone

Young, Elizabeth A.
Kwak, Seung P.
Kottak, Juliet

January 1995

Administration of exogenous glucocorticoids is known to suppress the HPA axis and has been reported ...

Impact of glucocorticoid receptor density on ligand-independent dimerization, cooperative ligand-binding and basal priming of transactivation: a cell culture model

Robertson, Steven
Rohwer, Johann M
Hapgood, Janet P
Louw, Ann

January 2013

Glucocorticoid receptor (GR) levels vary between tissues and individuals and are altered by physiolo...

Five patients with biochemical and/or clinical generalized glucocorticoid resistance without alterations in the glucocorticoid receptor gene

Huizenga, Nannette
Lange, Pieter
Koper, Jan
Herder, Wouter
Abs, R.
Kasteren, J.H.
Jong, Frank
Lamberts, Steven

January 2000

textabstractCortisol resistance (CR) is a rare disease characterized by a generalized red...

Decreased ligand affinity rather than glucocorticoid receptor down-regulation in patients with endogenous Cushing's syndrome

Huizenga N.A.T.M.
De Herder W.W.
Koper J.W.
De Lange P.
Lely A.J.V.D.
Brinkmann A.O.
De Jong F.H.
Lamberts S.W.J.

January 2000

Objective: Glucocorticoids (GCs) serve a variety of important functions throughout the body. The syn...

Molecular Mechanisms of Glucocorticoid Resistance in Corticotropinomas: New Developments and Drug Targets

Ciato, Denis
Albani, Adriana

January 2020

Cushing's disease is characterized by excessive adrenocorticotropin hormone (ACTH) secretion caused ...

Expression of the human glucocorticoid receptor splice variants α, β, and P in peripheral blood mononuclear leukocytes in healthy controls and in patients with hyper- and hypocortisolism

Hagendorf, A.
Koper, J.W. (Jan)
Jong, F.H. (Frank) de
Brinkmann, A.O. (Albert)
Lamberts, S.W.J. (Steven)
Feelders, R.A. (Richard)

November 2005

Context: The effects of cortisol are mediated by the α-isoform of the glucocorticoid receptor (GR). ...

Treatment with synthetic glucocorticoids and the hypothalamus-pituitary-adrenal axis

Paragliola, Rosa Maria (ORCID:0000-0002-5070-7771)
Papi, Giampaolo
Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865)
Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274)

January 2017

Chronic glucocorticoid (GC) treatment represents a widely-prescribed therapy for several diseases in...

Peripheral glucocorticoid receptor antagonism by relacorilant with modest HPA axis disinhibition

Viho, Eva M.G.
Kroon, Jan
Feelders, Richard A.
Houtman, René
van den Dungen, Elisabeth S.R.
Pereira, Alberto M.
Hunt, Hazel J.
Hofland, Leo J.
Meijer, Onno C.

February 2023

Glucocorticoid stress hormones are produced in response to hypothalamic-pituitary-adrenal (HPA) axis...

Contribution of Glucocorticoids and Glucocorticoid Receptors to the Regulation of Neurodegenerative Processes

Vyas, Sheela
Maatouk, Layal

December 2013

International audienceIsolation of glucocorticoids (GCs) from adrenal glands followed by synthesis l...

Pre-receptor Regulation of Cortisol in Hypothalamic-Pituitary-Adrenal Axis Functioning an Metabolism

Dekker, Marieke

January 2011

textabstractGlucocorticoids (GCs) are ubiquitous, nuclear hormones, which are essential for life. In...

Glucocorticoids are active players and therapeutic targets in atherosclerotic cardiovascular disease

Sluis, R.J. van der
Hoekstra, M.

January 2020

Adrenal-derived glucocorticoids mediate the physiological response to stress. Chronic disturbances i...

The Role of Glucocorticoid Receptor in the Pathophysiology of Pituitary Corticotroph Adenomas

Regazzo, Daniela
Mondin, Alessandro
Scaroni, Carla
Occhi, Gianluca
Barbot, Mattia

January 2022

Adrenocorticotropic Hormone (ACTH)-secreting pituitary adenomas are rare tumors characterized by aut...

Human glucocorticoid receptor cDNA contains sequences sufficient for receptor down-regulation.

Burnstein, K L
Jewell, C M
Cidlowski, J A

January 1990

Glucocorticoid receptors are ligand-dependent transcription factors that are subject to down-regulat...

The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity

Koorneef, L.L.
Kroon, J.
Viho, E.M.G.
Wahl, L.F.
Heckmans, K.M.L.
Dorst, M.M.A.R. van
Hoekstra, M.
Houtman, R.
Hunt, H.
Meijer, O.C.

July 2020

Glucocorticoids mediate numerous essential processes in the human body via binding to the glucocorti...

Treatment with Synthetic Glucocorticoids and the Hypothalamus-Pituitary-Adrenal Axis

Rosa Maria Paragliola

October 2017

Chronic glucocorticoid (GC) treatment represents a widely-prescribed therapy for several diseases in...

Negative Feedback Regulation following Administration of Chronic Exogenous Corticosterone

Young, Elizabeth A.
Kwak, Seung P.
Kottak, Juliet

January 1995

Administration of exogenous glucocorticoids is known to suppress the HPA axis and has been reported ...

Impact of glucocorticoid receptor density on ligand-independent dimerization, cooperative ligand-binding and basal priming of transactivation: a cell culture model

Robertson, Steven
Rohwer, Johann M
Hapgood, Janet P
Louw, Ann

January 2013

Glucocorticoid receptor (GR) levels vary between tissues and individuals and are altered by physiolo...

Five patients with biochemical and/or clinical generalized glucocorticoid resistance without alterations in the glucocorticoid receptor gene

Huizenga, Nannette
Lange, Pieter
Koper, Jan
Herder, Wouter
Abs, R.
Kasteren, J.H.
Jong, Frank
Lamberts, Steven

January 2000

textabstractCortisol resistance (CR) is a rare disease characterized by a generalized red...

Decreased ligand affinity rather than glucocorticoid receptor down-regulation in patients with endogenous Cushing's syndrome

Abstract

Extracted data

Decreased ligand affinity rather than glucocorticoid receptor down-regulation in patients with endogenous Cushing's syndrome

Abstract

Extracted data

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