A thermosensitive and photocrosslinkable composite polymer study for 3-D soft tissue scaffold printing

A novel biocompatible and biodegradable thermosensitive and photocrosslinkable material has been designed for use with solid freeform fabrication (SFF) printers. The blend of a thermosensitive poly (ethylene glycol-b-(DL-lactic acid-co-glycolic acid)-b-ethylene glycol), PEG-PLGA-PEG, triblock and photocrosslinkable PEG methacrylate-PLGA-PEG methacrylate, PEGma-PLGA-PEGma, allow for a material that is well suited for the fabrication of 3-D soft tissue scaffold printing. It is a solution of low viscosity at low temperature and becomes a highly viscous material with increase in temperature. Additional strength and irreversibility of the gel is gained with UV light irradiation.Other types of natural and synthesized materials were studied for use with SFF printers but none were capable of general use with a multiple number of printers because of specialized gelation steps or long solidification times. Thermosensitive and photocrosslinkable materials were also studied because of their simplicity allowing for the elimination of additional crosslinking material. Alone, each material is not able to build 3-D structures due to its mechanical abilities, but combined, the advantages of each material create a material that is ideal for soft tissue scaffold printing. This type of material allows for the integration of cell printing so that precise complex architecture can be accomplished with the incorporation of cells where needed in the scaffold.Ph.D., Biomaterials and Biomechanics -- Drexel University, 201