PURPOSE To obtain insight into the feasibility of, and the patients' perspective on, dried blood spot (DBS) self-sampling by patients with chronic myeloid leukemia (CML) using nilotinib. METHODS Sixty-eight patients with CML using nilotinib participated in this multicenter observational study. Patients were asked to perform blood sampling by means of the DBS method at home just before drug intake (trough level) and to complete a questionnaire including demographics and five questions on their experience with DBS self-sampling. RESULTS Sixty-one patients (57.5 ± 15.0 years, 49% female) provided 178 DBS samples of which 137 (77%) proved useful in clinical practice. Twenty percent of the samples were rejected because the spot size was too smal...
Contains fulltext : 167591.pdf (publisher's version ) (Closed access)Assessment of...
ABSTRACT: Dried blood spots (DBS) have been utilized in newborn screening programs for several years...
OBJECTIVES: Taking advantage of its food-dependent bioavailability, the present study investigated t...
Objectives: To compare nilotinib concentrations obtained by venous blood sampling and dried blood sp...
What is known and objective Dried blood spot (DBS) sampling is a minimally invasive method of blood ...
Background In large epidemiological studies it is often challenging to obtain biolog...
PURPOSE We investigated the population pharmacokinetics and exposure-response relationship of niloti...
BACKGROUND: Sampling of blood at home to determine the concentration of drugs or other compounds can...
The introduction and the extended clinical use of nilotinib in the first-line treatment of chronic m...
The introduction and the extended clinical use of nilotinib in the first-line treatment of chronic m...
The introduction and the extended clinical use of nilotinib in the first-line treatment of chronic m...
Introduction: This comprehensive observational study aimed to gain insight into adherence to nilotin...
Background: In chronic myeloid leukemia (CML), oral treatment needs to be taken indefinitely in the ...
Everolimus treatment is seriously hampered by its toxicity profile. As a relationship between everol...
Contains fulltext : 167591.pdf (publisher's version ) (Closed access)Assessment of...
ABSTRACT: Dried blood spots (DBS) have been utilized in newborn screening programs for several years...
OBJECTIVES: Taking advantage of its food-dependent bioavailability, the present study investigated t...
Objectives: To compare nilotinib concentrations obtained by venous blood sampling and dried blood sp...
What is known and objective Dried blood spot (DBS) sampling is a minimally invasive method of blood ...
Background In large epidemiological studies it is often challenging to obtain biolog...
PURPOSE We investigated the population pharmacokinetics and exposure-response relationship of niloti...
BACKGROUND: Sampling of blood at home to determine the concentration of drugs or other compounds can...
The introduction and the extended clinical use of nilotinib in the first-line treatment of chronic m...
The introduction and the extended clinical use of nilotinib in the first-line treatment of chronic m...
The introduction and the extended clinical use of nilotinib in the first-line treatment of chronic m...
Introduction: This comprehensive observational study aimed to gain insight into adherence to nilotin...
Background: In chronic myeloid leukemia (CML), oral treatment needs to be taken indefinitely in the ...
Everolimus treatment is seriously hampered by its toxicity profile. As a relationship between everol...
Contains fulltext : 167591.pdf (publisher's version ) (Closed access)Assessment of...
ABSTRACT: Dried blood spots (DBS) have been utilized in newborn screening programs for several years...
OBJECTIVES: Taking advantage of its food-dependent bioavailability, the present study investigated t...