Mechanically reducing regional left ventricular wall stress and improving ejection fraction in heart failure patients

Urgert, T
Halfwerk, F.R.
van den Heuvel, M.
Hagmeijer, Rob
Grandjean, J.G.

Publication date

April 2019

Abstract

IntroductionHeart failure with a reduced Ejection Fraction (HFrEF) is a progressive disease with a low 5-year survival of <50%, affecting 23 million people. It is characterized by adverse remodelling of the left ventricle (dilated cardiomyopathy). For every 5% increase in EF there is a 13% decrease in mortality. Pharmacological treatment and cardiac resynchronisation therapy have proven beneficial for survival. However, HFrEF still remains a progressive deadly disease. In HFrEF myocardial wall stress is increased and wall stress reduction might prevent or even reverse remodelling. Some devices, superficially constraining the dilated heart, have shown EF-increase and promote reverse remodelling. However, current devices cannot adapt to left ...

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Mechanically reducing regional left ventricular wall stress and improving ejection fraction in heart failure patients

Abstract

Extracted data

Mechanically reducing regional left ventricular wall stress and improving ejection fraction in heart failure patients

Abstract

Extracted data

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