Cumulative live birth rates in more than 3,000 patients with poor ovarian response: a 15-year survey of final in vitro fertilization outcome

Objective: To estimate the cumulative live birth rates (CLBRs) in women with poor ovarian response (POR) diagnosed according to the Bologna criteria. Design: A 15-year population-based observational cohort study. Setting: Teaching hospital. Patient(s): Between 2002 and 2016 a total of 3,391 women with POR were followed from their first fresh, nondonor IVF cycle until they had a live birth or discontinued treatment. All IVF and intracytoplasmic sperm injection (ICSI) cycles and cryocycles were included. Intervention(s): None. Main Outcome Measure(s): Live birth rates per initiated cycle, the conservative and optimistic CLBR for multiple IVF cycles. Result(s): The CLBRs after six IVF cycles were 14.9% for the conservative and 35.3% for the optimistic estimate. The CLBR decreased from 22% for women ≤30 years to 18.3% for women aged 31–34 years, 17.2% for 35–37 years, 13.5% for 38–40 years, 10.5% for 41–43 years, and 4.4% among women >43 years in the conservative analysis. There was a significant decreased CLBR starting at age 38 years compared with women 43 years old. Natural cycle IVF is of no benefit for these patients