C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta-analysis
- Kaptoge, Stephen
- Di Angelantonio, Emanuele
- Lowe, Gordon
- Pepys, Mark B.
- Thompson, Simon G.
- Collins, Rory
- Danesh, John
- Tipping, R. W.
- Ford, C. E.
- Pressel, S. L.
- Walldius, G.
- Jungner, I.
- Folsom, A. R.
- Chambless, L.
- Ballantyne, C. M.
- Panagiotakos, D.
- Pitsavos, C.
- Chrysohoou, C.
- Stefanadis, C.
- Knuiman, M. W.
- Goldbourt, U.
- Benderly, M.
- Tanne, D.
- Whincup, P.
- Wannamethee, S. G.
- Morris, R. W.
- Kiechl, S.
- Willeit, J.
- Mayr, A.
- Schett, G.
- Wald, N.
- Ebrahim, S.
- Lawlor, D.
- Yarnell, J.
- Gallacher, J.
- Casiglia, E.
- Tikhonoff, V.
- Nietert, P. J.
- Sutherland, S. E.
- Bachman, D. L.
- Keil, J. E.
- Cushman, M.
- Psaty, B. M.
- Tracy, R.
- Tybjærg-Hansen, A.
- Nordestgaard, B. G.
- Zacho, J.
- Frikke-Schmidt, R.
- Giampaoli, S.
- Palmieri, L.
- Panico, S.
- Vanuzzo, D.
- Pilotto, L.
- De La Cámara, A. Gómez
- Gómez Gerique, J. A.
- Simons, L.
- McCallum, J.
- Friedlander, Y.
- Fowkes, F. G.R.
- Lee, A.
- Taylor, J.
- Guralnik, J. M.
- Phillips, C. L.
- Wallace, R. B.
- Blazer, D. G.
- Khaw, K. T.
- Brenner, H.
- Raum, E.
- Müller, H.
- Rothenbacher, D.
- Jansson, J. H.
- Wennberg, P.
- Nissinen, A.
- Donfrancesco, C.
- Harald, K.
- Jousilahti, P.
- Vartiainen, E.
- Woodward, M.
- D’Agostino, R. B.
- Wolf, P. A.
- Vasan, R. S.
- Rosengren, A.
- Bladbjerg, E. M.
- Jørgensen, T.
- Møller, L.
- Jespersen, J.
- Dankner, R.
- Chetrit, A.
- Lubin, F.
- Rosengren, A.
- Wilhelmsen, L.
- Lappas, G.
- Eriksson, H.
- Björkelund, C.
- Lissner, L.
- Bengtsson, C.
- Cremer, P.
- Nagel, D.
- Tilvis, R. S.
- Strandberg, T. E.
- Kiyohara, Y.
- Arima, H.
- Doi, Y.
- Ninomiya, T.
- Rodriguez, B.
- Dekker, J.
- Nijpels, G.
- Stehouwer, C. D.A.
- Rimm, E.
- Pai, J. K.
- Sato, S.
- Iso, H.
- Kitamura, A.
- Noda, H.
- Salonen, J. T.
- Nyyssönen, K.
- Tuomainen, T. P.
- Laukkanen, J. A.
- Deeg, D. J.H.
- Bremmer, M. A.
- Meade, T. W.
- Cooper, J. A.
- Hedblad, B.
- Berglund, G.
- Engström, G.
- Verschuren, W. M.M.
- Blokstra, A.
- Shea, S.
- Döring, A.
- Koenig, W.
- Meisinger, C.
- Bueno-De-Mesquita, H. B.
- Kuller, L. H.
- Grandits, G.
- Selmer, R.
- Tverdal, A.
- Nystad, W.
- Gillum, R. F.
- Mussolino, M.
- Hankinson, S.
- Manson, J. E.
- Knottenbelt, C.
- Bauer, K. A.
- Davidson, K.
- Kirkland, S.
- Shaffer, J.
- Korin, M. R.
- Naito, Y.
- Holme, I.
- Nakagawa, H.
- Miura, K.
- Ducimetiere, P.
- Jouven, X.
- Luc, G.
- Crespo, C. J.
- Garcia-Palmieri, M. R.
- Amouyel, P.
- Arveiler, D.
- Evans, A.
- Ferrieres, J.
- Schulte, H.
- Assmann, G.
- Packard, C. J.
- Sattar, N.
- Westendorp, R. G.
- Buckley, B. M.
- Cantin, B.
- Lamarche, B.
- Després, J. P.
- Dagenais, G. R.
- Barrett-Connor, E.
- Wingard, D. L.
- Bettencourt, R. R.
- Gudnason, V.
- Aspelund, T.
- Sigurdsson, G.
- Thorsson, B.
- Trevisan, M.
- Witteman, J.
- Kardys, I.
- Breteler, M. M.B.
- Hofman, A.
- Tunstall-Pedoe, H.
- Tavendale, R.
- Howard, B. V.
- Zhang, Y.
- Best, L.
- Umans, J.
- Ben-Shlomo, Y.
- Davey-Smith, G.
- Onat, A.
- Njølstad, I.
- Mathiesen, E. B.
- Løchen, M. L.
- Wilsgaard, T.
- Ingelsson, E.
- Basu, S.
- Cederholm, T.
- Byberg, L.
- Gaziano, J. M.
- Stampfer, M.
- Ridker, P. M.
- Ulmer, H.
- Diem, G.
- Concin, H.
- Tosetto, A.
- Rodeghiero, F.
- Wassertheil-Smoller, S.
- Marmot, M.
- Clarke, R.
- Fletcher, A.
- Brunner, E.
- Shipley, M.
- Buring, J.
- Shepherd, J.
- Cobbe, S.
- Ford, I.
- Robertson, M.
- He, Y.
- Marin Ibañez, A.
- Feskens, E. J.M.
- Walker, M.
- Watson, S.
- Erqou, S.
- Lewington, S.
- Pennells, L.
- Perry, P. L.
- Ray, K. K.
- Sarwar, N.
- Alexander, M.
- Thompson, A.
- White, I. R.
- Wood, A. M.
DOIAbstract
Background Associations of C-reactive protein (CRP) concentration with risk of major diseases can best be assessed by long-term prospective follow-up of large numbers of people. We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances. Methods We meta-analysed individual records of 160 309 people without a history of vascular disease (ie, 1·31 million person-years at risk, 27 769 fatal or non-fatal disease outcomes) from 54 long-term prospective studies. Within-study regression analyses were adjusted for within-person variation in risk factor levels. Results Loge CRP concentration was linearly associated with several conventional risk factors and inflammatory markers, an...
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