25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study
- Tromp, Ilse I. M.
- Franco, Oscar H.
- van den Hooven, Edith H.
- Heijboer, Annemieke C.
- Jaddoe, Vincent W. V.
- Duijts, Liesbeth
- de Jongste, Johan C.
- Moll, Henriëtte A.
- Kiefte-de Jong, Jessica C.
DOIAbstract
Background & aims: A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter resistance (Rint), physician diagnosed asthma ever, wheezing and eczema in a population-based cohort study in 6 year old children. Methods: Serum 25(OH) vitamin D concentration was assessed in 3815 children. 25(OH) vitamin D concentrations ≥75 nmol/L were considered as sufficient, between 50 and 75 nmol/L as insufficient, and <50...
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