Diminished P-glycoprotein (P-gp)-mediated transport across the blood-brain barrier may play an important role in several neurodegenerative disorders. In previous studies, a racemic mixture of (R)-[11C]verapamil and (S)-[11C]verapamil has been used as tracer for assessing P-gp function using positron emission tomography (PET). Quantification, however, is compromised by potential differences in kinetics between these two isomers. The aim of the present study was to evaluate the kinetics of pure (R)-[ 11C]verapamil in humans and to develop a tracer kinetic model for the analysis of P-gp-mediated transport of (R)-[11C]verapamil, including the putative contribution of its radioactive metabolites. Dynamic (R)-[ 11C]verapamil PET scans of 10 male ...
(R)-[11C]verapamil is a radiotracer widely used for the evaluation of the P-glycoprotein (P-gp) func...
ABSTRACT: BACKGROUND: This study investigated the influence of P-glycoprotein (P-gp) inhibitor tariq...
Purpose: P-glycoprotein (P-gp) function is altered in several brain disorders; thus, it is of intere...
Diminished P-glycoprotein (P-gp)-mediated transport across the blood-brain barrier may play an impor...
There is evidence that P-glycoprotein (P-gp) in the blood-brain barrier (BBB) may be involved in the...
There is evidence that P-glycoprotein (P-gp) in the blood-brain barrier (BBB) may be involved in the...
There is evidence that P-glycoprotein (P-gp) in the blood-brain barrier (BBB) may be involved in the...
(R)-[(11)C]verapamil is a radiotracer widely used for the evaluation of the P-glycoprotein (P-gp) fu...
Background P-glycoprotein [Pgp] dysfunction may be involved in neurodegenerative diseases, such as A...
P-glycoprotein in the blood–brain barrier (BBB) has been found to be associated with several t...
Objectives: P-glycoprotein (P-gp) is found at cell membranes of various organs, also at the blood-br...
P-glycoprotein in the blood–brain barrier (BBB) has been found to be associated with several types o...
The blood-brain barrier (BBB) is a functional barrier that hampers the delivery of various drugs to ...
The blood-brain barrier (BBB) is a functional barrier that hampers the delivery of various drugs to ...
(R)-[11C]verapamil is a radiotracer widely used for the evaluation of the P-glycoprotein (P-gp) func...
ABSTRACT: BACKGROUND: This study investigated the influence of P-glycoprotein (P-gp) inhibitor tariq...
Purpose: P-glycoprotein (P-gp) function is altered in several brain disorders; thus, it is of intere...
Diminished P-glycoprotein (P-gp)-mediated transport across the blood-brain barrier may play an impor...
There is evidence that P-glycoprotein (P-gp) in the blood-brain barrier (BBB) may be involved in the...
There is evidence that P-glycoprotein (P-gp) in the blood-brain barrier (BBB) may be involved in the...
There is evidence that P-glycoprotein (P-gp) in the blood-brain barrier (BBB) may be involved in the...
(R)-[(11)C]verapamil is a radiotracer widely used for the evaluation of the P-glycoprotein (P-gp) fu...
Background P-glycoprotein [Pgp] dysfunction may be involved in neurodegenerative diseases, such as A...
P-glycoprotein in the blood–brain barrier (BBB) has been found to be associated with several t...
Objectives: P-glycoprotein (P-gp) is found at cell membranes of various organs, also at the blood-br...
P-glycoprotein in the blood–brain barrier (BBB) has been found to be associated with several types o...
The blood-brain barrier (BBB) is a functional barrier that hampers the delivery of various drugs to ...
The blood-brain barrier (BBB) is a functional barrier that hampers the delivery of various drugs to ...
(R)-[11C]verapamil is a radiotracer widely used for the evaluation of the P-glycoprotein (P-gp) func...
ABSTRACT: BACKGROUND: This study investigated the influence of P-glycoprotein (P-gp) inhibitor tariq...
Purpose: P-glycoprotein (P-gp) function is altered in several brain disorders; thus, it is of intere...