Neonatal gram negative and Candida sepsis survival and neurodevelopmental outcome at the corrected age of 24 months

de Haan, Timo R
Beckers, Loes
de Jonge, Rogier C J
Spanjaard, Lodewijk
van Toledo, Letty
Pajkrt, Dasja
van Wassenaer-Leemhuis, Aleid G
van der Lee, Johanna H

Open link

Publication date

January 2013

DOI

10.1371/journal.pone.0059214

Publisher

Public Library of Science (PLoS)

Abstract

OBJECTIVES: To evaluate the long term neurodevelopmental outcome of premature infants exposed to either gram- negative sepsis (GNS) or neonatal Candida sepsis (NCS), and to compare their outcome with premature infants without sepsis. METHODS: Historical cohort study in a population of infants born at <30 weeks gestation and admitted to the Neonatal Intensive Care Unit (NICU) of the Academic Medical Center in Amsterdam during the period 1997-2007. Outcome of infants exposed to GNS or NCS and 120 randomly chosen uncomplicated controls (UC) from the same NICU were compared. Clinical data during hospitalization and neurodevelopmental outcome data (clinical neurological status; Bayley-test results and vision/hearing test results) at the correcte...