The clinical value of the patient-reported multiple sclerosis neuropsychological screening questionnaire

Nauta, Ilse M
Balk, Lisanne J
Sonder, Judith M
Hulst, Hanneke E
Uitdehaag, Bernard Mj
Fasotti, Luciano
de Jong, Brigit A

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Publication date

October 2019

DOI

10.1177/1352458518777295

Publisher

SAGE Publications

Abstract

BACKGROUND: Cognitive problems are difficult to identify in patients with multiple sclerosis (MS). OBJECTIVE: To investigate the clinical applicability of the patient-reported MS Neuropsychological Screening Questionnaire (MSNQ-P). METHODS: Cut-off scores were determined to differentiate between cognitively impaired ( n = 90), mildly cognitively impaired ( n = 115), and cognitively preserved ( n = 147) MS patients using receiver operating characteristic analyses. RESULTS: We could not define specific and sensitive cut-off scores. Higher scores (≥27) did indicate cognitive impairment. Among patients with a higher education, lower scores (<12) indicated intact cognition. CONCLUSION: Certain scores can indicate intact or impaired cognitive fun...