The goal of this study was to evaluate the validity of the pretreated, unilaterally MPTP-treated monkey as an animal model of Parkinson's disease (PD). For that purpose, a detailed ethogram was developed and assessed in four male rhesus monkeys that had received MPTP (2.5 mg) in the carotid artery contralateral to the dominant limb. Subsequently, the behavioural effects of the dopamine D2 agonist quinpirole and the dopamine D1 agonist SKF 81297 were studied. The ethogram was found to allow a clear-cut and objective separation of drug-induced behaviours into therapeutic and undesired effects in the MPTP-treated monkeys. Saline-treated monkeys predominantly displayed ipsilateral goal-directed fore-limb movements, and distinct types of ipsilat...
International audienceThe cardinal symptoms of Parkinson's disease (PD), akinesia, rigidity and trem...
The neuroprotective efficacy of the propargylamine TCH346 was studied in the primate model of Parkin...
Parkinson's disease is a progressive neurodegenerative disorder, characterized by a loss of dopamine...
Item does not contain fulltextThe goal of this study was to evaluate the validity of the pretreated,...
The aim of this study was twofold: (1) to study the predictive validity of the drug-naive, bilateral...
Rationale: SKF 83959 acts as a D1 antagonist in vitro but has been claimed to induce anti-parkinsoni...
The cynomolgus monkeys received a unilateral intracarotid injection of the neurotoxin N-methyl-4-phe...
Item does not contain fulltextThe aim of this study was twofold: (1) to study the predictive validit...
Administration of the indirect agonist L-dopa, the nonselective direct agonist apomorphine, or the s...
The alleged selective, high efficacy dopamine D1 receptor agonist, SKF 81297 (0.05-0.3 mg/kg i.m.), ...
International audienceThe cardinal symptoms in Parkinson's disease (PD), akinesia, rigidity and trem...
The MPTP-lesioned monkey is considered as the best animal model for Parkinson's disease (PD). It has...
The stable 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian (HP) rhesus ...
Parkinson’s disease is a movement disorder, caused predominantly by the degeneration of the dopamine...
Almost no information is available concerning the link between clinical effects of dopamine D2 recep...
International audienceThe cardinal symptoms of Parkinson's disease (PD), akinesia, rigidity and trem...
The neuroprotective efficacy of the propargylamine TCH346 was studied in the primate model of Parkin...
Parkinson's disease is a progressive neurodegenerative disorder, characterized by a loss of dopamine...
Item does not contain fulltextThe goal of this study was to evaluate the validity of the pretreated,...
The aim of this study was twofold: (1) to study the predictive validity of the drug-naive, bilateral...
Rationale: SKF 83959 acts as a D1 antagonist in vitro but has been claimed to induce anti-parkinsoni...
The cynomolgus monkeys received a unilateral intracarotid injection of the neurotoxin N-methyl-4-phe...
Item does not contain fulltextThe aim of this study was twofold: (1) to study the predictive validit...
Administration of the indirect agonist L-dopa, the nonselective direct agonist apomorphine, or the s...
The alleged selective, high efficacy dopamine D1 receptor agonist, SKF 81297 (0.05-0.3 mg/kg i.m.), ...
International audienceThe cardinal symptoms in Parkinson's disease (PD), akinesia, rigidity and trem...
The MPTP-lesioned monkey is considered as the best animal model for Parkinson's disease (PD). It has...
The stable 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian (HP) rhesus ...
Parkinson’s disease is a movement disorder, caused predominantly by the degeneration of the dopamine...
Almost no information is available concerning the link between clinical effects of dopamine D2 recep...
International audienceThe cardinal symptoms of Parkinson's disease (PD), akinesia, rigidity and trem...
The neuroprotective efficacy of the propargylamine TCH346 was studied in the primate model of Parkin...
Parkinson's disease is a progressive neurodegenerative disorder, characterized by a loss of dopamine...