Angiogenic Risk Factors in Women Ten Years after Severe, Very Early Onset Preeclampsia

Objective: To evaluate angiogenic risk factor parameters in women with a history of severe, very early onset preeclampsia Background: Severe, early onset preeclampsia is associated with preceding of high levels of anti angiogenic factors. Epidemiological studies have demonstrated an association between preeclampsia and future maternal cardiovascular disease, which is also associated with increased anti angiogenic factors. Both preeclampsia and cardiovascular disease share classic risk factors, however for angiogenic factors, as found in preeclampsia, its association is unknown. Study design: Women with a history of severe, early onset preeclampsia before 24 weeks’ gestation, defi ned according to the ISSHP (n=16), who delivered between 1993-2003 in a tertiary referral center were recruited. Plasma samples were analyzed by ELISA for basic fi broblast growth factor (bFGF), soluble fms-like tyrosine kinase-1 (sFlt-1), vascular endothelial growth factor (VEGF), E-, P-selectin, intercellular adhesion molecule-3 (ICAM-3) and thrombomodulin. Results: See article. Conclusion: We found no differences in angiogenic risk factors in women, ten years after their pregancy complicated by severe, very early onset preeclampsia compared to controls