In silico validation of the Autoinflammatory Disease Damage Index
- Haar, N.M.R. van der
- Delft, A.L.J. van
- Annink, K.V.
- Stel, H. van
- Al-Mayouf, S.M.
- Amaryan, G.
- Anton, J.
- Barron, K.S.
- Benseler, S.
- Brogan, P.A.
- Cantarini, L.
- Cattalini, M.
- Cochino, A.V.
- Benedetti, F. De
- Dedeoglu, F.
- Jesus, A.A. De
- Demirkaya, E.
- Dolezalova, P.
- Durrant, K.L.
- Fabio, G.
- Gallizzi, R.
- Goldbach-Mansky, R.
- Hachulla, E.
- Hentgen, V.
- Herlin, T.
- Hofer, M.
- Hoffman, H.M.
- Insalaco, A.
- Jansson, A.F.
- Kallinich, T.
- Kone-Paut, I.
- Kozlova, A.
- Kuemmerle-Deschner, J.B.
- Lachmann, H.J.
- Laxer, R.M.
- Martini, A.
- Nielsen, S.
- Nikishina, I.
- Ombrello, A.K.
- Ozen, S.
- Papadopoulou-Alataki, E.
- Quartier, P.
- Rigante, D.
- Russo, R.
- Simon, A.
- Trachana, M.
- Uziel, Y.
- Ravelli, A.
- Schulert, G.
- Gattorno, M.
- Frenkel, J.
DOIAbstract
INTRODUCTION: Autoinflammatory diseases can cause irreversible tissue damage due to systemic inflammation. Recently, the Autoinflammatory Disease Damage Index (ADDI) was developed. The ADDI is the first instrument to quantify damage in familial Mediterranean fever, cryopyrin-associated periodic syndromes, mevalonate kinase deficiency and tumour necrosis factor receptor-associated periodic syndrome. The aim of this study was to validate this tool for its intended use in a clinical/research setting. METHODS: The ADDI was scored on paper clinical cases by at least three physicians per case, independently of each other. Face and content validity were assessed by requesting comments on the ADDI. Reliability was tested by calculating the intracla...