Study protocol of the randomised placebo-controlled GLOBE trial: GL P-1 f o r b ridging of hyperglyca e mia during cardiac surgery
- Hulst, Abraham H.
- Visscher, Maarten J.
- Godfried, Marc B.
- Thiel, Bram
- Gerritse, Bas M.
- Scohy, Thierry V.
- Bouwman, R. Arthur
- Willemsen, Mark G. A.
- Hollmann, Markus W.
- Devries, J. Hans
- Preckel, Benedikt
- Hermanides, Jeroen
DOIAbstract
Introduction Perioperative hyperglycaemia is common during cardiac surgery and associated with postoperative complications. Although intensive insulin therapy for glycaemic control can reduce complications, it carries the risk of hypoglycaemia. GLP-1 therapy has the potential to lower glucose without causing hypoglycaemia. We hypothesise that preoperative liraglutide (a synthetic GLP-1 analogue) will reduce the number of patients requiring insulin to achieve glucose values<8 mmol l -1 in the intraoperative period. Methods and analysis We designed a multi-centre randomised parallel placebo-controlled trial and aim to include 274 patients undergoing cardiac surgery, aged 18-80 years, with or without diabetes mellitus. Patients will receive 0....
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