A genome-wide association search for type 2 diabetes genes in African Americans
- Palmer, Nicholette D.
- McDonough, Caitrin W.
- Hicks, Pamela J.
- Roh, Bong H.
- Wing, Maria R.
- An, S. Sandy
- Hester, Jessica M.
- Cooke, Jessica N.
- Bostrom, Meredith A.
- Rudock, Megan E.
- Talbert, Matthew E.
- Lewis, Joshua P.
- Ferrara, Assiamira
- Lu, Lingyi
- Ziegler, Julie T.
- Sale, Michele M.
- Divers, Jasmin
- Shriner, Daniel
- Adeyemo, Adebowale
- Rotimi, Charles N.
- Ng, Maggie C. Y.
- Langefeld, Carl D.
- Freedman, Barry I.
- Bowden, Donald W.
- Voight, Benjamin F
- Scott, Laura J
- Steinthorsdottir, Valgerdur
- Morris, Andrew P
- Dina, Christian
- Welch, Ryan P
- Zeggini, Eleftheria
DOIAbstract
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,...
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