A systematic review and narrative synthesis on the histological and neurobehavioral long-term effects of dexmedetomidine
- Hoorn, C.E. (Camille) van
- Hoeks, S.E. (Sanne)
- Essink, H. (Heleen)
- Tibboel, D. (Dick)
- Graaff, J.C. (Jurgen) de
DOIAbstract
Background: Recent experimental studies suggest that currently used anesthetics have neurotoxic effects on young animals. Clinical studies are increasingly publishing about the effects of anesthesia on the long‐term outcome, providing contradictory results. The selective alpha‐2 adrenergic receptor agonist dexmedetomidine has been suggested as an alternative nontoxic sedative agent. Aims: The aim of this systematic review was to assess the potential neuroprotective and neurobehavioral effects of dexmedetomidine in young
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