BackgroundCalcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a member of the Ca$^{2+}$/calmodulin-dependent kinase (CaMK) family involved in adiposity regulation, glucose homeostasis and cancer. This upstream activator of CaMKI, CaMKIV and AMP-activated protein kinase is inhibited by phosphorylation, which also triggers an association with the scaffolding protein 14-3-3. However, the role of 14-3-3 in the regulation of CaMKK2 remains unknown.MethodsThe interaction between phosphorylated CaMKK2 and the 14-3-3γ protein, as well as the architecture of their complex, were studied using enzyme activity measurements, small-angle x-ray scattering (SAXS), time-resolved fluorescence spectroscopy and protein crystallography.ResultsOur d...
Calmodulin kinase cascade is a signaling pathway which is involved in the response to the increasing...
Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) activates particular multifunctional kinases...
© 2018 Dr. Matthew O’BrienCa2+/Calmodulin dependent protein kinase kinase 2 (CaMKK2) is a serine-thr...
BackgroundCalcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a member of the Ca$^{2+}$...
Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) regulates several key physiological and p...
AbstractCa2+/calmodulin-dependent protein kinase kinase α (CaMKKα) plays critical roles in the modul...
The Ca2+ -signaling pathway is an important mechanism of cell signaling. Ca2+ /Cal- modulin (CaM)-de...
5 Abstract Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) belongs to the serine/ threoni...
Ca2 calmodulin dependent protein kinase kinase 2 CaMKK2 regulates several key physiological and p...
The calcium-calmodulin–dependent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and...
Through binding interactions with more than 300 binding partners, 14-3-3 proteins regulate large amo...
alcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2), a member of the Ca$^{2+}$/calmodulin-...
Through binding interactions with more than 300 binding partners, 14-3-3 proteins regulate large amo...
Ca2+/calmodulin-dependent protein kinase kinase β (CaMKKβ) acts as a regulatory kinase that phosphor...
Ca2+/calmodulin-dependent protein kinase kinase (CaMKK), a Ca2+/CaM-dependent enzyme that phosphoryl...
Calmodulin kinase cascade is a signaling pathway which is involved in the response to the increasing...
Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) activates particular multifunctional kinases...
© 2018 Dr. Matthew O’BrienCa2+/Calmodulin dependent protein kinase kinase 2 (CaMKK2) is a serine-thr...
BackgroundCalcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a member of the Ca$^{2+}$...
Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) regulates several key physiological and p...
AbstractCa2+/calmodulin-dependent protein kinase kinase α (CaMKKα) plays critical roles in the modul...
The Ca2+ -signaling pathway is an important mechanism of cell signaling. Ca2+ /Cal- modulin (CaM)-de...
5 Abstract Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) belongs to the serine/ threoni...
Ca2 calmodulin dependent protein kinase kinase 2 CaMKK2 regulates several key physiological and p...
The calcium-calmodulin–dependent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and...
Through binding interactions with more than 300 binding partners, 14-3-3 proteins regulate large amo...
alcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2), a member of the Ca$^{2+}$/calmodulin-...
Through binding interactions with more than 300 binding partners, 14-3-3 proteins regulate large amo...
Ca2+/calmodulin-dependent protein kinase kinase β (CaMKKβ) acts as a regulatory kinase that phosphor...
Ca2+/calmodulin-dependent protein kinase kinase (CaMKK), a Ca2+/CaM-dependent enzyme that phosphoryl...
Calmodulin kinase cascade is a signaling pathway which is involved in the response to the increasing...
Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) activates particular multifunctional kinases...
© 2018 Dr. Matthew O’BrienCa2+/Calmodulin dependent protein kinase kinase 2 (CaMKK2) is a serine-thr...