The characteristic sea surface salinity (SSS) patterns associated with the tropical Atlantic meridional and equatorial interannual modes are extracted from in situ observations, by a statistical analysis performed on the 1980–2012 period. These SSS signatures of the interannual climatic modes are reproduced in a regional numerical simulation. For each mode, oceanic and/or atmospheric processes driving the SSS signature are identified through a mixed‐layer salt budget in the validated model. During a positive meridional mode in spring, a northward shift of the Intertropical Convergence Zone and related precipitation maximum creates a south‐north dipole of positive‐negative SSS anomalies around the equator. Western boundary currents strengthe...