We study diffusion and mixing in different linear fluid dynamics models, mainly related to incompressible flows. In this setting, mixing is a purely advective effect which causes a transfer of energy to high frequencies. When diffusion is present, mixing enhances the dissipative forces. This phenomenon is referred to as enhanced dissipation, namely the identification of a time-scale faster than the purely diffusive one. We establish a precise connection between quantitative mixing rates in terms of decay of negative Sobolev norms and enhanced dissipation time-scales. The proofs are based on a contradiction argument that takes advantage of the cascading mechanism due to mixing, an estimate of the distance between the inviscid and viscous dyn...