It is anticipated that bioactive fragments of the extracellular matrix (matrikines) can influence the development and progression of chronic diseases. The enzyme leukotriene A4 hydrolase (LTA4H) mediates opposing proinflammatory and anti-inflammatory activities, through the generation of leukotriene B4 (LTB4) and degradation of proneutrophilic matrikine Pro-Gly-Pro (PGP), respectively. We show that abrogation of LTB4 signaling ameliorated inflammation and airway hyperresponsiveness (AHR) in a murine asthma model, yet global loss of LTA4H exacerbated AHR, despite the absence of LTB4. This exacerbated AHR was attributable to a neutrophil-independent capacity of PGP to promote pathological airway epithelial remodeling. Thus, we demonstrate a d...
Abstract. Chronic stable asthma is characterized by inflammation of the airway wall, with abnormal a...
Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their imp...
Background: Asthma is an airway inflammatory disease with functional and structural changes, leading...
It is anticipated that bioactive fragments of the extracellular matrix (matrikines) can influence th...
Neutrophil mobilization, recruitmentand clearancemust be tightly regulated asover-exuberant neutroph...
Background: Airway remodeling has recently emerged as a major problem in an increasing percentage of...
Bronchial asthma is a heterogeneous disease with complex pathological mechanisms representing differ...
The Author(s) 2015. This article is published with open access at Springerlink.com Abstract The airw...
Although asthma is defined in terms of reversibility of airflow obstruction, as the disease becomes ...
© 2019, Privolzhsky Research Medical University. All rights reserved. Bronchial asthma is associated...
In severe asthma, cytokines and growth factors contribute to the proliferation of smooth muscle cell...
BACKGROUND: Airway smooth muscle (ASM) cells are fundamental to asthma pathogenesis, influencing bro...
Contains fulltext : 142683.pdf (publisher's version ) (Closed access)BACKGROUND: T...
Allergic asthma is a chronic inflammatory disease of the lung. It is thought to arise as a result of...
Full list of author information is available at the end of the articleAirway inflammation and fibros...
Abstract. Chronic stable asthma is characterized by inflammation of the airway wall, with abnormal a...
Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their imp...
Background: Asthma is an airway inflammatory disease with functional and structural changes, leading...
It is anticipated that bioactive fragments of the extracellular matrix (matrikines) can influence th...
Neutrophil mobilization, recruitmentand clearancemust be tightly regulated asover-exuberant neutroph...
Background: Airway remodeling has recently emerged as a major problem in an increasing percentage of...
Bronchial asthma is a heterogeneous disease with complex pathological mechanisms representing differ...
The Author(s) 2015. This article is published with open access at Springerlink.com Abstract The airw...
Although asthma is defined in terms of reversibility of airflow obstruction, as the disease becomes ...
© 2019, Privolzhsky Research Medical University. All rights reserved. Bronchial asthma is associated...
In severe asthma, cytokines and growth factors contribute to the proliferation of smooth muscle cell...
BACKGROUND: Airway smooth muscle (ASM) cells are fundamental to asthma pathogenesis, influencing bro...
Contains fulltext : 142683.pdf (publisher's version ) (Closed access)BACKGROUND: T...
Allergic asthma is a chronic inflammatory disease of the lung. It is thought to arise as a result of...
Full list of author information is available at the end of the articleAirway inflammation and fibros...
Abstract. Chronic stable asthma is characterized by inflammation of the airway wall, with abnormal a...
Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their imp...
Background: Asthma is an airway inflammatory disease with functional and structural changes, leading...