Patient reported outcome measures for transperineal template prostate mapping biopsies in the PICTURE study

Purpose: Transperineal prostate mapping (TTPM) biopsy is an increasingly utilized method of procuring tissue from men with suspected prostate cancer. We sought to report the patient related outcome measures (PROMs) and adverse events in men undergoing this diagnostic test within the PICTURE trial. Material and Methods: 249 men underwent a mpMRI followed by a TTPM biopsy as a validation study. Pre-and post-TTPM functional outcomes were prospectively collected and recorded using IPSS, IPSS-QoL, IIEF-15 and EPIC-Urinary function questionnaires. Results: Mean age, median PSA and median gland size was 62 years, 6.8 ng/ml and 37ml, respectively. At TTPM biopsy, a median (IQR) 49 (40-55) cores were taken. Mean time for completion of post-procedure PROMs questionnaires was 46 days. Adverse events included post procedure acute urinary retention (24%), rectal pain (26%) and perineal pain (41%). TTPM-biopsy resulted in a statistically significant increase in IPSS (10.9 to 11.8; p=0.024) and IPSS-QoL score (1.57 to 1.76; p=0.03). The erectile function score on IIEF-15 declined by 23.2% (47.7 to 38.7; p<0.001). Significant deterioration in all 5 functional domains of IIEF-15 (erectile and orgasmic function, sexual desire, intercourse and overall satisfaction; p