Dynamic molecular changes during the first week of human life follow a robust developmental trajectory.
- Lee, Amy H
- Shannon, Casey P
- Amenyogbe, Nelly
- Bennike, Tue B
- Diray-Arce, Joann
- Idoko, Olubukola T
- Gill, Erin E
- Ben-Othman, Rym
- Pomat, William S
- van Haren, Simon D
- Cao, Kim-Anh Lê
- Cox, Momoudou
- Darboe, Alansana
- Falsafi, Reza
- Ferrari, Davide
- Harbeson, Daniel J
- He, Daniel
- Bing, Cai
- Hinshaw, Samuel J
- Ndure, Jorjoh
- Njie-Jobe, Jainaba
- Pettengill, Matthew A
- Richmond, Peter C
- Ford, Rebecca
- Saleu, Gerard
- Masiria, Geraldine
- Matlam, John Paul
- Kirarock, Wendy
- Roberts, Elishia
- Malek, Mehrnoush
- Sanchez-Schmitz, Guzmán
- Singh, Amrit
- Angelidou, Asimenia
- Smolen, Kinga K
- EPIC Consortium
- Brinkman, Ryan R
- Ozonoff, Al
- Hancock, Robert EW
- van den Biggelaar, Anita HJ
- Steen, Hanno
- Tebbutt, Scott J
- Kampmann, Beate
- Levy, Ofer
- Kollmann, Tobias R
DOIAbstract
Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and co...
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