Presence of chemotherapy-induced toxicity predicts improved survival in patients with localised extremity osteosarcoma treated with doxorubicin and cisplatin: a report from the European Osteosarcoma Intergroup.
- McTiernan, A
- Jinks, RC
- Sydes, MR
- Uscinska, B
- Hook, JM
- van Glabbeke, M
- Bramwell, V
- Lewis, IJ
- Taminiau, AH
- Nooij, MA
- Hogendoorn, PC
- Gelderblom, H
- Whelan, JS
DOIAbstract
Chemotherapy-induced toxicity is an independent prognostic indicator in several cancers. We aimed to determine whether toxicity was related to survival and histological response in high-grade localised extremity osteosarcoma. We undertook a retrospective analysis of patients treated within three consecutive randomised controlled trials (RCTs) of the European Osteosarcoma Intergroup
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