Age of Transfused Blood in Critically Ill Adults
- Lacroix, Jacques
- Hébert, Paul C.
- Fergusson, Dean A.
- Tinmouth, Alan
- Cook, Deborah J.
- Marshall, John C.
- Clayton, Lucy
- Mcintyre, Lauralyn
- Callum, Jeannie
- Turgeon, Alexis F.
- Blajchman, Morris A.
- Walsh, Timothy S.
- Stanworth, Simon J.
- Campbell, Helen
- Capellier, Gilles
- Tiberghien, Pierre
- Bardiaux, Laurent
- van de Watering, Leo
- van Der Meer, Nardo J.
- Sabri, Elham
- Vo, Dong
- Souweine, Canadian Critical Care Trials Group
DOIAbstract
International audienceBetween March 2009 and May 2014, at 64 centers in Canada and Europe, 1211 patients were assigned to receive fresh red cells (fresh-blood group) and 1219 patients were assigned to receive standard-issue red cells (standard-blood group). Red cells were stored a mean (±SD) of 6.1±4.9 days in the fresh-blood group as compared with 22.0±8.4 days in the standard-blood group (P<0.001). At 90 days, 448 patients (37.0%) in the fresh-blood group and 430 patients (35.3%) in the standard-blood group had died (absolute risk difference, 1.7 percentage points; 95% confidence interval [CI], -2.1 to 5.5). In the survival analysis, the hazard ratio for death in the fresh-blood group, as compared with the standard-blood group, was 1.1 (9...
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