In human prostate cancer (PCa), the neuroendocrine cells, expressing the prostate cancer stem cell (CSC) marker CD44, may be resistant to androgen ablation and promote tumor recurrence. During the study of heterogeneity of the highly aggressive neuroendocrine PCa cell lines PC3 and DU-145, we isolated and expanded in vitro a minor subpopulation of very small cells lacking CD44 (CD44neg). Unexpectedly, these sorted CD44neg cells rapidly and spontaneously converted to a stable CD44high phenotype specifically expressing the CD44v8-10 isoform which the sorted CD44high subpopulation failed to express. Surprisingly and potentially interesting, in these cells expression of CD44v8-10 was found to be induced in stem cell medium. CD44 variant isoform...
PMCID: PMC3577706This is an open-access article distributed under the terms of the Creative Commons ...
Androgen-deprivation therapy is the standard treatment for prostate cancer. Despite the initial resp...
CD44 is a glycosylated adhesion molecule which may undergo alternative splicing to generate variant ...
The expression of certain CD44 variants has been linked with metastasis and tumour progression. In p...
Recently, various human tumors have been shown to contain stem-like cells called cancer stem cells. ...
Objective: Bone metastasis is a clinically important outcome of prostate carcinoma (PC). We focused ...
Existing therapies for prostate cancer eradicates the bulk of cells within a tumor. However, most pa...
Patients receiving docetaxel developed a drug resistance within a few months. We generated docetaxel...
licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that th...
Prostate cancer (PCa) is the most frequently diagnosed malignancy in men worldwide. Chemotherapy res...
An increasing number of malignancies has been shown to be initiated and propelled by small subpopula...
Stem cells may play a role in the development and maintenance of proliferative diseases of the prost...
[[abstract]]Patients receiving docetaxel developed a drug resistance within a few months. We generat...
Abstract Background Dysregulated expression and splicing of cell adhesion marker CD44 is found in ma...
textThe recently resurrected cancer stem cell (CSC) theory sheds new light on understanding tumor bi...
PMCID: PMC3577706This is an open-access article distributed under the terms of the Creative Commons ...
Androgen-deprivation therapy is the standard treatment for prostate cancer. Despite the initial resp...
CD44 is a glycosylated adhesion molecule which may undergo alternative splicing to generate variant ...
The expression of certain CD44 variants has been linked with metastasis and tumour progression. In p...
Recently, various human tumors have been shown to contain stem-like cells called cancer stem cells. ...
Objective: Bone metastasis is a clinically important outcome of prostate carcinoma (PC). We focused ...
Existing therapies for prostate cancer eradicates the bulk of cells within a tumor. However, most pa...
Patients receiving docetaxel developed a drug resistance within a few months. We generated docetaxel...
licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that th...
Prostate cancer (PCa) is the most frequently diagnosed malignancy in men worldwide. Chemotherapy res...
An increasing number of malignancies has been shown to be initiated and propelled by small subpopula...
Stem cells may play a role in the development and maintenance of proliferative diseases of the prost...
[[abstract]]Patients receiving docetaxel developed a drug resistance within a few months. We generat...
Abstract Background Dysregulated expression and splicing of cell adhesion marker CD44 is found in ma...
textThe recently resurrected cancer stem cell (CSC) theory sheds new light on understanding tumor bi...
PMCID: PMC3577706This is an open-access article distributed under the terms of the Creative Commons ...
Androgen-deprivation therapy is the standard treatment for prostate cancer. Despite the initial resp...
CD44 is a glycosylated adhesion molecule which may undergo alternative splicing to generate variant ...